Changes in L-PF Dyspnoea and Cough scores across strata of 52-week change in global quality of life score
| Change in L-PF global quality of life score† | F-statistic‡ | Pairwise comparisons§ | ||||||||||
| Large deterioration | Minimal/Moderate deterioration | Stable | Minimal/Moderate improvement | Large improvement | ||||||||
| N | Mean (SD) change from baseline | N | Mean (SD) change from baseline | N | Mean (SD) change from baseline | N | Mean (SD) change from baseline | N | Mean (SD) change from baseline | |||
| L-PF Dyspnoea score | 7 | 10.8 (29.6) | 167 | 9.4 (16.1) | 240 | 5.4 (14.4) | 115 | −0.1 (16.1) | 7 | 4.1 (15.7) | 6.7*** | 6***, 8* |
| L-PF Cough score | 7 | 1.8 (31.8) | 165 | 6.9 (24.4) | 238 | −0.5 (21.2) | 115 | −4.9 (27.2) | 7 | −6.0 (25.6) | 4.7** | 6** |
L-PF Symptoms scores range from 0 to 100, with higher scores indicating greater impairment.
*P<0.05, **p<0.01, ***p<0.001.
†Question 21: on average, over the last 7 days, how has your quality of life been? Scale: 0 (extremely poor) to 4 (excellent). Large deterioration: change of −3 or −4; minimal/moderate deterioration: change of −2 or −1; stable: change of 0; minimal/moderate improvement: change of +1 or +2; large improvement: change of +3 or +4.
‡One-way analyses of variance (generalised linear model) overall F-statistic.
§Pairwise comparisons using Scheffe’s method: 1=large deterioration versus minimal/moderate deterioration, 2=large deterioration versus stable, 3=large deterioration versus minimal/moderate improvement, 4=large deterioration versus large improvement, 5=minimal/moderate deterioration versus stable, 6=minimal/moderate deterioration versus minimal/moderate improvement, 7=minimal/moderate deterioration versus large improvement, 8=stable versus minimal/moderate improvement, 9=stable versus large improvement, 10=minimal/moderate improvement versus large improvement.
L-PF, Living with Pulmonary Fibrosis.