Study period | ||||||
Visits | Screening | Baseline | Physical therapist (first visit) | Physical therapist (training) | Physical therapist (last visit) | Close-out |
Timepoint | −7 to −2 days | Day 0 | Day 1 (±3) | Days 1–90 (weekly) | Day 90 (±5) | Day 90 (±7) |
Enrolment | ||||||
Eligibility screen | x | |||||
Informed consent | x | |||||
Medical history | x | |||||
Physical examination | x | |||||
Pulmonary function test | x | |||||
CPET | x | |||||
Echocardiography | x | |||||
Health-related QoL | x | |||||
Blood sample | x | |||||
Allocation | x | |||||
Interventions | ||||||
Usual care | x | x | ||||
IMT programme | x | x | x | |||
Assessments | ||||||
PeakVO2 | x | x | ||||
VE/VCO2 slope | x | x | ||||
Chronotropic response | x | x | ||||
Health-related QoL | x | x | ||||
Inspiratory Muscle Strength test | x | x | x |
CPET, cardiopulmonary exercise testing; IMT, inspiratory muscle training; QoL, quality of life; VE/VCO2 slope, ventilatory efficiency.