qSOFA | SOFA | CURB-65 | ROX index | 4C | ||||||||
GCS score | <15 | +1 | GCS score | 13–14 | +1 | GCS score | <15 | +1 | GCS score | <15 | +2 | |
RR (/min) | ≥22 | +1 | 10–12 | +2 | RR (/min) | ≥30 | +1 | RR (/min) | 20–29 | +1 | ||
SBP (mm Hg) | ≤100 | +1 | 6–9 | +3 | SBP (mm Hg) | <90 | ≥30 | +2 | ||||
<6 | +4 | DBP (mm Hg) | <60 | +1 | SpO2 (%) | <92 | +2 | |||||
PaO2/FiO2 (mm Hg) | <400 | +1 | Urea (mg/dL) | >19 | +1 | Urea (mmol/L) | 7–14 | +1 | ||||
<300 | +2 | Age (years) | ≥65 | +1 | >14 | +3 | ||||||
<200 | +3 | Age (years) | 50–59 | +2 | ||||||||
<100 | +4 | 60–69 | +4 | |||||||||
MBP (mm Hg) | <70 | +1 | 70–79 | +6 | ||||||||
NE (μg/kg/min) | >0.1 | +4 | ≥80 | +7 | ||||||||
Creatinine (mg/dL) | 1.2–1.9 | +1 | Gender | Male | +1 | |||||||
2–3.4 | +2 | CRP (mg/dL) | 50–99 | +1 | ||||||||
3.5–4.9* | +3 | ≥100 | +2 | |||||||||
>5† | +4 | Comorbidities | 1 | +1 | ||||||||
Liver bilirubin (mg/dL) | 1.2–1.9 | +1 | ≥2 | +2 | ||||||||
2–5.9 | +2 | |||||||||||
6–11.9 | +3 | |||||||||||
>12 | +4 | |||||||||||
Thrombocytes (103/mm3) | <150 | +1 | ||||||||||
<100 | +2 | |||||||||||
<50 | +3 | |||||||||||
<20 | +4 |
*Or 24-hour urine output <500 mL/day.
†Or 24-hour urine output <200 mL/day.
4C, Coronavirus Clinical Characterisation Consortium; CRP, C reactive protein; CURB-65, Confusion, Uraemia, Respiratory Rate, Blood Pressure and Age ≥65; DBP, diastolic blood pressure; FiO2, fraction of inspired oxygen; GCS, Glasgow Coma Scale; MBP, mean blood pressure; NE, norepinephrine; PaO2, partial pressure of arterial oxygen; qSOFA, Quick Sequential Organ Failure Assessment; ROX, Respiratory Rate and Oxygenation; RR, respiratory rate; SBP, systolic blood pressure; SOFA, Sequential Organ Failure Assessment; SpO2, saturation of peripheral oxygen.