Table 2

Asthma-related and obesity-related PRS in asthma and non-asthma participants among adults aged 30–70 years, Taiwan Biobank

CharacteristicSampleAsthma, n=2072Non-asthma, n=8288Crude OR
(95% CI)
P value
Asthma PRS0.00±1.000.63±0.95−0.16±0.952.40 (2.26 to 2.54)<0.001
Obesity indicators PRS*
 BMI0.00±1.000.08±1.02−0.02±1.001.10 (1.05 to 1.16)<0.001
 WC0.00±1.000.10±1.01−0.02±1.001.14 (1.08 to 1.19)<0.001
 WHtR0.00±1.000.07±1.00−0.02±1.001.09 (1.04 to 1.15)<0.001
General obesity PRS†
 BMI0.00±1.000.05±0.99−0.01±1.001.07 (1.02 to 1.12)0.010
Central obesity PRS†
 WC0.00±1.000.06±1.02−0.02±1.001.08 (1.03 to 1.13)0.002
 WHtR0.00±1.000.07±0.99−0.02±1.001.09 (1.04 to 1.14)<0.001
General–central obesity PRS‡
 BMI+WC0.00±1.000.05±0.99−0.01±1.001.07 (1.02 to 1.12)0.008
 BMI+WHtR0.00±1.000.05±1.00−0.01±1.001.06 (1.01 to 1.11)0.018
  • Polygenic risk scores were standardised to mean=0 and SD=1 for the analysis.

  • *Obesity measures were continuous variables.

  • †Obesity measures were binary variables (obese vs non-obese groups).

  • ‡Obesity measures were binary variables (two obesity traits vs other groups).

  • BMI, body mass index; PRS, polygenic risk scores; WC, waist circumference; WHtR, waist-to-height ratio.