Table 3

Associations between obesity and asthma in adults aged 30–70 years, Taiwan Biobank

VariableModel 1Model 2
OR (95% CI)P valueOR (95% CI)P value
BMI
 Phenotype 1 (ref: normal)
  Underweight0.83 (0.57 to 1.19)0.307
  Overweight1.13 (0.99 to 1.30)0.068
  Obese1.32 (1.14 to 1.54)<0.001
 Phenotype 2 (ref: non-obese)
  Obese1.26 (1.10 to 1.45)<0.001
 BMI PRS1.07 (1.01 to 1.13)0.020
 General obesity PRS1.04 (0.98 to 1.10)0.236
WC
 Phenotype (ref: non-obese)
  Obese1.26 (1.12 to 1.41)<0.001
 WC PRS1.10 (1.04 to 1.17)<0.001
 Central obesity PRS1.06 (<1.00 to 1.12)0.057
WHtR
 Phenotype (ref: non-obese)
  Obese1.27 (1.13 to 1.44)<0.001
 WHtR PRS1.05 (0.99 to 1.11)0.103
 Central obesity PRS1.09 (1.03 to 1.15)0.003
Two obesity traits
 Phenotype
  BMI (obese)+WC (obese)1.27 (1.10 to 1.46)<0.001
  BMI (obese)+WHtR (obese)1.27 (1.11 to 1.46)<0.001
 General–central obesity PRS
  BMI (obese)+WC (obese)1.06 (1.00 to 1.12)0.036
  BMI (obese)+WHtR (obese)1.03 (0.98 to 1.09)0.241
  • Adjustments include PRS of asthma, education, one of the parents has asthma, one of the siblings has asthma, chronic obstructive pulmonary disease, depression, gastro-oesophageal reflux disease, hypertension and PM2.5.

  • BMI, body mass index; PRS, polygenic risk scores; WC, waist circumference; WHtR, waist-to-height ratio.