Variable | Model 1 | Model 2 | ||
OR (95% CI) | P value | OR (95% CI) | P value | |
BMI | ||||
Phenotype 1 (ref: normal) | ||||
Underweight | 0.83 (0.57 to 1.19) | 0.307 | – | – |
Overweight | 1.13 (0.99 to 1.30) | 0.068 | – | – |
Obese | 1.32 (1.14 to 1.54) | <0.001 | – | – |
Phenotype 2 (ref: non-obese) | ||||
Obese | 1.26 (1.10 to 1.45) | <0.001 | – | – |
BMI PRS | – | – | 1.07 (1.01 to 1.13) | 0.020 |
General obesity PRS | – | – | 1.04 (0.98 to 1.10) | 0.236 |
WC | ||||
Phenotype (ref: non-obese) | ||||
Obese | 1.26 (1.12 to 1.41) | <0.001 | – | – |
WC PRS | – | – | 1.10 (1.04 to 1.17) | <0.001 |
Central obesity PRS | – | – | 1.06 (<1.00 to 1.12) | 0.057 |
WHtR | ||||
Phenotype (ref: non-obese) | ||||
Obese | 1.27 (1.13 to 1.44) | <0.001 | – | – |
WHtR PRS | – | – | 1.05 (0.99 to 1.11) | 0.103 |
Central obesity PRS | – | – | 1.09 (1.03 to 1.15) | 0.003 |
Two obesity traits | ||||
Phenotype | ||||
BMI (obese)+WC (obese) | 1.27 (1.10 to 1.46) | <0.001 | – | – |
BMI (obese)+WHtR (obese) | 1.27 (1.11 to 1.46) | <0.001 | – | – |
General–central obesity PRS | ||||
BMI (obese)+WC (obese) | – | – | 1.06 (1.00 to 1.12) | 0.036 |
BMI (obese)+WHtR (obese) | – | – | 1.03 (0.98 to 1.09) | 0.241 |
Adjustments include PRS of asthma, education, one of the parents has asthma, one of the siblings has asthma, chronic obstructive pulmonary disease, depression, gastro-oesophageal reflux disease, hypertension and PM2.5.
BMI, body mass index; PRS, polygenic risk scores; WC, waist circumference; WHtR, waist-to-height ratio.