Change in BPI severity score associated with each increment of EQ-5D-5L
| Incremental increase in response to EQ-5D-5L pain and discomfort question | Associated change in median response to BPI pain severity score | Adjusted p value |
| Baseline intervention | ||
| Increment 1–2 | 2 (1.75–2.88) | 0.06 |
| Increment 2–3 | 2.38 (1.25–3.13) | <0.01 |
| Increment 3–4 | 1.75 (1.00–2.75) | 0.01 |
| Increment 4–5 | 1.63 (0.88–2.25) | 0.1 |
| Intervention 3 months | ||
| Increment 1–2 | 2 (1.38–3.00) | 0.01 |
| Increment 2–3 | 2.5 (1.25–3.63) | 0.01 |
| Increment 3–4 | 1.88 (0.50–3.25) | 0.04 |
| Increment 4–5 | 2.25 (0.75–3.86) | 0.19 |
| Intervention 12 months | ||
| Increment 1–2 | 2.75 (1.25–3.75) | 0.01 |
| Increment 2–3 | 1.63 (0.25–2.75) | 0.14 |
| Increment 3–4 | 2 (0.75–3.50) | 0.07 |
| Increment 4–5 | 2.13 (−2.75 to 3.63) | 0.66 |
| Usual care cohort 12 months | ||
| Increment 1–2 | 1.25 (0.25–1.88) | 0.49 |
| Increment 2–3 | 3.00 (2.13–4.00) | <0.01 |
| Increment 3–4 | 3.25 (1.88–4.25) | 0.02 |
| Increment 4–5 | −0.50 (−2.50 to 0.88) | 0.71 |
Change in median BPI responses associated with incremental change in EQ-5D-5L response with pairwise comparisons. Statistically significant changes in median responses are highlighted in bold to demonstrate the discriminatory power of the EQ-5D-5L in detecting differences in pain severity.
BPI, Brief Pain Inventory; EQ-5D-5L, EuroQol 5 Dimension 5 Level.