Histological scoring of central and peripheral IPF lung explant biopsies
| Central (N=13) | Peripheral (N=13) | Paired t-test p value | |
| *Pathological classification | |||
| UIP pathology | 3 (patchy) | 13 (subpleural) | |
| NSIP | 2 | 0 | |
| UIP/NSIP overlap | 2 | 0 | |
| CIPU | 5 | 0 | |
| E/PIF | 1 | 0 | |
| Fibrosis score (average±SD) | 1.15±0.375 | 2.85±0.375 | <0.0001 |
| 1 | 11 | 0 | |
| 2 | 2 | 2 | |
| 3 | 0 | 11 | |
| Fibroblastic foci (average±SD) | 1.08±0.862 | 2.08±0.862 | 0.0059 |
| 0 | 3 | 0 | |
| 1 | 7 | 4 | |
| 2 | 2 | 4 | |
| 3 | 1 | 5 | |
| Honeycomb (average±SD) | 0.31±0.48 | 1±0 | 0.0002 |
| 0 | 9 | 0 | |
| 1 | 4 | 13 | |
| Inflammation foci (average±SD) | 6.46±3.971 | 12.08±6.601 | 0.0103 |
| 1–7 | 7 | 3 | |
| 8–14 | 6 | 5 | |
| 15–21 | 0 | 5 | |
| Pulmonary hypertension grade (average±SD) | 1.69±0.63 | 2.69±0.48 | 0.0019 |
| 1 | 5 | 0 | |
| 2 | 7 | 4 | |
| 3 | 1 | 9 |
CIPU, chronic interstitial pneumonitis, unclassifiable; E, emphysema; IPF, idiopathic pulmonary fibrosis; IPF.C, IPF lung explants of the central regions; IPF.P, IPF lung explants of the peripheral regions; NSIP, non-specific interstitial pneumonitis; PIF, patchy non-specific interstitial fibrosis; UIP, usual interstitial pneumonia.