Table 2

Cox proportional hazard regression analyses of factors affecting lung transplant survival

Variable	Univariate (unadjusted HR, 95% CI)	P value	Multivariate (aHR, 95% CI) All eras	P value	Multivariate (aHR, 95% CI) 1987–2000	P value	Multivariate (aHR, 95% CI) 2001–2010	P value	Multivariate (aHR, 95% CI) 2011–2020	P value
Age at transplantation ≥50	1.76 (1.27 to 2.49)	0.0010	2.36 (1.55 to 3.72)	0.0001	8.01 (1.16 to 113.0)	0.0669	2.71 (1.47 to 5.24)	0.0021	2.49 (1.27 to 5.38)	0.0124
Sex, male	0.96 (0.70 to 1.32)	0.7837	1.01 (0.68 to 1.52)	0.9789	3.12 (0.43 to 33.96)	0.2770	0.68 (0.35 to 1.36)	0.2609	1.17 (0.69 to 2.08)	0.5709
Type of transplant, bilateral	0.75 (0.55 to 1.00)	0.0569	0.87 (0.61 to 1.26)	0.4688	0.08 (0.00 to 0.97)	0.0908	0.73 (0.36 to 1.41)	0.3552	1.06 (0.61 to 1.89)	0.8497
Corticosteroids at time of transplantation	1.50 (1.04 to 2.24)	0.0378	1.14 (0.74 to 1.79)	0.5691			0.76 (0.41 to 1.45)	0.3896	1.78 (0.96 to 3.43)	0.0740
Antifibrotics at time of transplantation	0.86 (0.40 to 1.61)	0.6614	1.05 (0.47 to 2.10)	0.8937					1.21 (0.52 to 2.55)	0.6425
6MWT at assessment, < 275 m	1.38 (0.99 to 1.92)	0.0572	1.38 (0.97 to 1.97)	0.0774	1.73 (0.23 to 12.53)	0.5744	0.76 (0.43 to 1.36)	0.3544	1.71 (1.02 to 2.88)	0.0432
Primary lung disease
IPF	Reference		Reference		Reference		Reference		Reference
Fibrotic NSIP	2.07 (1.15 to 3.50)	0.0099	2.61 (1.40 to 4.60)	0.0015			4.25 (1.49 to 10.53)	0.0032	1.86 (0.80 to 3.95)	0.1218
CTD-ILD	1.43 (0.70 to 2.61)	0.2766	2.11 (0.96 to 4.16)	0.0435			2.52 (0.57 to 7.82)	0.1526	1.99 (0.77 to 4.56)	0.1222
cHP	0.90 (0.41 to 1.74)	0.7844	1.01 (0.44 to 2.01)	0.9736			1.04 (0.24 to 3.10)	0.9474	0.69 (0.22 to 1.75)	0.4657
Sarcoidosis	0.64 (0.36 to 1.07)	0.1113	0.96 (0.45 to 1.87)	0.9246	0.09 (0.00 to 1.27)	0.1068	0.74 (0.26 to 1.79)	0.5347	0.88 (0.21 to 2.58)	0.8397
Others	1.34 (0.74 to 2.25)	0.3017	1.56 (0.83 to 2.72)	0.1411			1.50 (0.52 to 3.77)	0.4096	2.14 (0.78 to 5.24)	0.1111

Significant p-values are highlighted in bold.
aHR, adjusted HR; cHP, chronic hypersensitivity pneumonitis; CTD-ILD, connective tissue disease-related interstitial lung disease; IPF, idiopathic pulmonary fibrosis; 6MWT, 6 min walk test; NSIP, non-specific interstitial pneumonia.