Eligibility criteria
Aged <3 years of age
Evidence of RTI (any of the following):
Feels hot or temperature of >37.8°C
Cough
Nose: Snotty, stuffy, blocked
Earache
Sore throat
Sneezing
Evidence of lower RTI (any of the following)*:
Audible wheezing (without auscultation)
Shortness of breath, rapid or shallow breathing for age
Oxygen saturations <94% on air
Crackles, wheeze or diminished breath sounds on auscultation
Respiratory distress: apnoea, nasal flaring, chest recession, grunting, head bobbing
Central cyanosis
History of above symptoms if intubated prior to site admission
Parent/carer unable to provide informed consent on behalf of the child
Parent/carer unable to conform to study requirements
Participated within STOP RSV within the last 30 days
(SAM Strip subgroup only): nasal flaring on examination
*Not necessary for upper RTI subgroup.
RSV, respiratory syncytial virus; RTI, respiratory tract infection; SAM, synthetic absorptive matrix.