Table 1

Baseline demographics for ECLIPSE and ERICA cohorts*

VariableECLIPSEERICA
Males (N=1296)Male (N=386)Female (N=244)
NNN
Age (years)129663.9 (7.1)38667.9 (7.99)24466.5 (7.28)
BMI (kg/m2)129626.7 (5.2)38627.3 (5.26)24427.5 (6.39)
Height (m)3861.73 (0.07)2441.59 (0.07)
Weight (kg)38681.4 (17.7)24469.4 (17.0)
FFM (kg)36957.4 (9.13)23941.7 (5.95)
Obese (BMI>30 kg/m2)386114 (30%)24476 (31%)
Smoking status: current1296449 (35%)386114 (30%)24481 (33%)
Free testosterone (ng/dL)†3866.39 (2.87)2440.31 (0.85)
Total testosterone (ng/dL)1296459.1 (197.1)386455.0 (199.9)24427.5 (56.4)
FEV1 (L)3861.52 (0.542)2441.07 (0.353)
FEV1 (%)38651.5 (16.6)24453.2 (15.1)
GOLD stage:
 21296542 (42%)386217 (56%)244143 (59%)
 3559 (43%)122 (32%)87 (35%)
 4195 (15%)47 (12%)14 (6%)
BODE‡ index3732 (1, 5)2303 (1, 5)
MMRC‡3861 (1, 3)2432 (1, 3)
6MWD (m)373359 (130)231324 (125)
SPPB: chair stand time (s)‡37612.50 (10.00, 15.83)23812.6 (10.05, 17.08)
Gait time (s)‡3834.03 (3.30, 4.76)2404.50 (3.70, 5.70)
QMVC (kg)37435.5 (10.76)23722.7 (7.44)
aPWV (m/s)‡35810.05 (8.50, 11.98)2229.45 (8.20, 11.18)
cIMT (mm)3510.851 (0.189)2220.829 (0.204)
  • *Statistics summarised using mean (SD) for continuous variables and n (%) for categorical variables unless otherwise specified.

  • †Free testosterone calculated by the EFT formula.14 28 29 Where free-t estimated from the EFT formula resulted in negative values, these were taken to be 0.001 ng/dL.

  • ‡Statistics summarised using median (IQR).

  • aPWV, aortic pulse wave velocity; BMI, body mass index; BODE, body mass index(B), degree of obstruction(O), dyspnoea(D) and exercise capacity(E); cIMT, carotid intima–media thickness; ECLIPSE, Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points; EFT, empirical free testosterone; ERICA, Evaluation of the Role of Inflammation in Chronic Airways; FEV1, forced expiratory volume in 1 s; FFM, fat free mass; GOLD, global initiative for obstructive lung disease; LOS, length of stay; mMRC, modified Medical Research Council; 6MWD, 6 min walk distance; QMVC, quadriceps maximum voluntary contraction; SPPB, short physical performance battery.