Table 5

Univariable and multivariable regression models for the effect of total testosterone on outcomes in the ERICA and ECLIPSE cohorts in GOLD stage 2 male patients with COPD

CohortOutcomeModel adjustmentOR (95% CI)*P value
ECLIPSE (N=542)ACMUnadjusted0.2360.003
Adjusted†0.2480.007
H-AECOPDUnadjusted0.6650.314
Adjusted†0.6100.255
ERICA (N=217)ACMUnadjusted0.619 (0.365 to 1.065)0.068
Adjusted†0.558 (0.316 to 0.948)0.030
H-AECOPDUnadjusted1.028 (0.624 to 1.868)0.920
Adjusted†1.038 (0.611 to 2.007)0.900
  • *95% CIs not available for ECLIPSE.

  • †Adjusted for age, BMI, FEV1 and smoking status.

  • ACM, all-cause mortality; COPD, chronic obstructive pulmonary disease; ECLIPSE, Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points; ERICA, Evaluation of the Role of Inflammation in Chronic Airways; FEV1, forced expiratory volume in 1 s; GOLD, Global Initiative for Obstructive Lung Disease; H-AECOPD, hospitalised acute exacerbation of chronic obstructive pulmonary disorder.