Table 4

Representative quotes relating to potential clinical trial outcomes for children with an acute asthma exacerbation

Work of breathing“You have to see his face. The way you do your research for me is all right, shortness of breath, all that, they’re able to see it instantly” – Mother of 14 year-old, Argentina
“He needed oxygen because he couldn’t breathe. He was short of breath…. We wanted [him] to feel better.” – Mother of 4 year-old, Argentina
“At that point, what is most important is to see the child breathing better because it’s the fast breathing and the fact that your child cannot make a complete sentence that really scares you. Like, is he going to suddenly stop breathing? The most reassuring part is to see that the child is breathing better.” – Mother of 3 year-old, Nigeria
“Just get his breathing under control is what I want.” – Grandmother of 12 year-old, USA
“The worst I probably been, is that I didn’t get no air, at all. I couldn’t breathe, at all. There was no hard, intense wheezing. I could not breathe, at all.” – 12 year old (patient), USA
“If she had gotten better at that hospital, I don’t think we would have come here… You guys did an amazing job. I remember coming here, I was literally crying, and in six or seven hours, she was close to stable.” – Mother of 2 year-old, Nigeria
Intensive care admission“For me, it wasn’t really important that he went to ICU because I know there’s other sick kids in ICU, and so I didn’t really care where he went just as long as he was getting the monitoring that he was needing.” – Mother of 6 year-old, Australia
“….When they said it was intensive care, it was like saying, “This is serious”.” – Mother of 5 year-old, Costa Rica
“It’s preferable if they don’t end up in intensive care because they spend a lot of time alone there, and they put a mask on their face, and they become desperate. It’s much better here, in the emergency room … and I’m with him.” – Mother of 6 year-old, Paraguay
[Going to intensive care] would be terrible… It would be very horrible.” – Mother of 5 year-old, Qatar.
Length of stay and speed of recovery“What worries me the most is that he will have a long stay in the hospital again this time. Because I’m busy with my work, I have no time to take care of my child…. It’s a sheer torture for me to stay with my child in the hospital, because I have to give up too many opportunities to make money. For me, time is money.” – Father of 5 year-old, China
“What he says is he has to stay longer. Then my husband has to take [unpaid leave], this kind of thing.” Mother of 3 year-old, Singapore
“No one likes to come to hospital. I hate coming to hospital whether I’m a patient or visiting or bringing your child in. I don’t like it. I never have….” - Mother of 8 year-old, Australia
“I suppose how quickly the patients respond and getting them back to health quickly and staying healthy…. He’s a four and half year-old boy. He wants to get out there and play. That’s what’s important to me, having a healthy little boy.” – Mother of 4 year-old, Australia
“It is important to know what to expect when your child receives treatment and how long it’s going to take for them to get better so that we, as parents, can have peace of mind and accompany our children in the process.” – Parent of 9 year-old, Paraguay
“I would prefer a drug that saves days of hospitalization.” – Mother of 9 year-old, Spain
Side effects of treatment“If a new treatment method is introduced, I am most concerned about its efficacy and side effects. If it works well and has little side effects, I can accept it.” – Father of 8 year-old, China
“I’m very resistant to intravenous injection, because I think the side-effects of injection is great…. I prefer to accept the method that is the least harmful and safest to the patient’s body.” – Mother of 5 year-old, China
“We should be careful not to irritate children with treatment, that the treatment doesn’t cause them pain…” – Mother of 6 year-old, Paraguay
Costs“I am most concerned about … cost. Even if its treatment effect is good…, if the cost is too high, I cannot afford it.” Mother of 4 year-old, China.
Satisfaction with treatment“It’s better to have not only quantitative study, qualitative to see the patient experience and if they are satisfied with it, and also with a couple of follow-ups to see if there is any improvement.” – Mother of 5 year-old, Qatar.