Within-group and between-group statistical analyses
| Within-group difference from pre-PR (post-PR–pre-PR) | Between-group differences | |||
| Control-group | HI-NIV group | HI-NIV group–control-group | P value | |
| Subjects | 13 | 13 | ||
| CET | ||||
| Time, s | 141 (60 to 222)* | 246 (61 to 432)* | 105 (−92 to 302) | 0.608 |
| Time, % change | 56 (29 to 83)* | 99 (22 to 175)* | 43 (−35 to 120) | 0.665 |
| 6MWT | ||||
| Distance, m | 41 (15 to 67)* | 50 (16 to 84)* | 9 (−31 to 50) | 0.645 |
| HADS, pts | ||||
| Anxiety | −0.4 (−2.4 to 1.8) | −2.0 (−3.8 to −0.22)* | −1.6 (−4.3 to 0.9) | 0.182 |
| Depression | 0.1 (−0.9 to 1.0) | −0.6 (−2.0 to 0.75) | −0.7 (−2.3 to 0.9) | 0.361 |
| CRQ, pts | ||||
| Total | 0.4 (−0.8 to 0.9) | 1.0 (0.7 to 1.4)* | 0.6 (0.1 to 1.2)† | 0.023 |
| Dyspnoea | 0.2 (−0.4 to 0.9) | 0.8 (0.06 to 1.6)* | 0.6 (−0.3 to 1.5) | 0.134 |
| Fatigue | 0.4 (−0.1 to 1.0) | 1.0 (0.5 to 1.7)* | 0.6 (−0.1 to 1.4) | 0.104 |
| Emotional function | 0.4 (−0.0 to 0.8) | 1.2 (0.8 to 1.6)* | 0.8 (0.2 to 1.3)† | 0.011 |
| Mastery | 0.5 (−0.1 to 1.1) | 1.0 (0.6 to 1.5)* | 0.5 (−0.1 to 1.2) | 0.091 |
| SRI, pts | ||||
| Summary scale | 0.6 (−3.4 to 4.6) | −3.4 (−8.2 to 1.2) | −4 (−9.9 to 1.7) | 0.075 |
| Knee extension peak force | ||||
| N | 20 (−19 to 61) | 26 (9 to 42)* | 6 (−36 to 47) | 0.621 |
| % pred | 8 (−4 to 21) | 7 (2 to 13)* | −1(−14 to 12) | 0.849 |
Data presented as mean (95% CI).
*Significant within-group difference from pre-PR.
†Significant between-group difference.
CET, Cycle Endurance Test; CRQ, Chronic Respiratory Disease questionnaire; HADS, Hospital Anxiety and Depression Scale; 6MWD, 6-Min Walk Test; NIV, nocturnal non-invasive ventilation; PR, pulmonary rehabilitation; SRI, Severe Respiratory Insufficiency questionnaire.