Table 3

28-day mortality in the subgroup analyses

HyperoxiaNo hyperoxiaOR95% CI
Age
 <65 years4.9% (0.0–11.5%)11.4% (2.0–20.7%)0.400.73 to 2.19
 ≥65 years38.1% (28.8–47.4%)21.5% (14.2–28.8%)2.251.25 to 4.04
Chronic cardiopulmonary disease*
 (−)28.8% (21.1–36.5%)14.0% (8.1–19.8%)2.491.35 to 4.60
 (+)26.7% (4.3–49.0%)39.3% (21.2–57.4%)0.560.14 to 2.22
Source of infection confirmed
 Pulmonary12.8% (2.3–23.3%)18.2% (2.1–34.3%)0.660.16 to 2.78
 Extrapulmonary34.3% (25.3–43.2%)18.9% (12.5–25.3%)2.241.26 to 3.99
Septic shock
 (−)29.0% (20.4–37.6%)17.2% (10.5–23.9%)1.961.05 to 3.68
 (+)27.5% (13.7–41.3%)23.3% (10.6–35.9%)1.250.47 to 3.37
Without hypoxia†28.8% (21.4–36.1%)18.8% (12.8–24.7%)1.751.03 to 2.97
  • IPW analyses were performed in each subgroup.

  • *Chronic cardiopulmonary diseases included congestive heart failure, coronary artery disease and chronic lung diseases.

  • †Hypoxia was defined as PaO2 <60 mm Hg.

  • IPW, inverse probability weighting; PaO2, arterial partial pressure of oxygen.