The relationship between blood eosinophil percentage and corticosteroid treatment failure among inpatients with AECOPD
| Case, n (%) | Unadjusted OR (95% CI) | Multiadjusted OR (95% CI) | |
| Treatment failure | |||
| EOS <2% | 623 (32.9) | Reference | Reference |
| EOS ≥2% | 335 (22.2) | 0.58 (0.50 to 0.68) | 0.74 (0.63 to 0.87) |
| Length of stay ≥14 days | |||
| EOS <2% | 474 (25.0) | Reference | Reference |
| EOS ≥2% | 244 (16.2) | 0.58 (0.49 to 0.69) | 0.71 (0.60 to 0.86) |
| Transfer to ICU | |||
| EOS <2% | 110 (5.8) | Reference | Reference |
| EOS ≥2% | 18 (1.2) | 0.20 (0.12 to 0.32) | 0.31 (0.18 to 0.52) |
| Invasive mechanical ventilation | |||
| EOS <2% | 38 (2.0) | Reference | Reference |
| EOS ≥2% | 7 (0.5) | 0.23 (0.10 to 0.51) | 0.40 (0.71 to 0.93) |
| Incident pneumonia during hospitalisation | |||
| EOS <2% | 59 (3.1) | Reference | Reference |
| EOS ≥2% | 49 (3.2) | 1.05 (0.71 to 1.54) | 1.08 (0.72 to 1.61) |
| Death during hospitalisation or within 30 days after discharge | |||
| EOS <2% | 57 (3.0) | Reference | Reference |
| EOS ≥2% | 12 (0.8) | 0.26 (0.14 to 0.48) | 0.42 (0.22 to 0.81) |
| AECOPD readmission within 30 days after discharge | |||
| EOS <2% | 96 (5.0) | Reference | Reference |
| EOS ≥2% | 58 (3.8) | 0.76 (0.54 to 1.06) | 0.99 (0.69 to 1.41) |
Adjusted for age, gender, Charlson Comorbidity Index, smoking status, number of AECOPD hospitalisations in the previous year, white blood cell count and antibiotics use.
AECOPD, acute exacerbations of chronic obstructive pulmonary disease; EOS, eosinophil percentage; ICU, intensive care unit.