Table 1

Baseline characteristics for all patients in the analytical sample divided by exposure (N=938)

CharacteristicLow EN* n=632Early goal EN* n=306P value
Age, mean±SD62.9±16.165.2±16.30.04
Male sex, N (%)357 (56.5)139 (45.4)<0.01
BMI, mean±SD29.7±8.930.4±9.90.30
APACHE II, mean±SD26.0±7.823.4±7.0<0.01
Infection at baseline, N (%)565 (89.4)270 (88.2)0.59
Vasopressors days 0–2, N (%)†417 (66.2)142 (46.7)<0.01
Neuromuscular blockade, days 0–2, N (%)†251 (39.8)133 (43.8)0.26
Died in hospital, N (%)243 (38.4)79 (25.8)<0.01
Pre-existing hypertension, N (%)420 (66.5)219 (71.6)0.24
Pre-existing diabetes, N (%)247 (39.1)126 (41.2)0.71
  • *'Low EN’ indicates patients who did not achieve 70% of recommended EN within 2 calendar days of intubation; ‘Early goal EN’ indicates patients who did achieve 70% of recommended EN within 2 calendar days of intubation.

  • †Control n=630; intervention n=304 for vasopressors and neuromuscular blockade during baseline period.

  • APACHE II, Acute Physiology and Chronic Health Evaluation II; BMI, body mass index; EN, enteral nutrition.