Clinical studyLung volumes in exacerbations of asthma☆
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Cited by (114)
Functional Assessment of Asthma
2016, Pediatric Allergy: Principles and Practice: Third EditionInfection-Related Asthma
2014, Journal of Allergy and Clinical Immunology: In PracticeCitation Excerpt :Physiological changes also occur in the airways of individuals with asthma in response to infection. More than 5 decades ago, it was noted that significant changes in lung function occur in patients with asthma during infection, with decreases in FEV1 and forced vital capacity as well as evidence of increased air trapping.51 Animal models show that viral airway injury at an early age may induce small airway lesions that are associated with small airway physiological dysfunction, which may persist into maturity.52
Lessons from the world trade center disaster: Airway disease presenting as restrictive dysfunction
2013, ChestCitation Excerpt :Kaminsky and Irvin5 obtained pathologic specimens in a patient with reversible restriction due to asthma and demonstrated terminal airway inflammation. In addition, increased VC without change in FEV1/VC frequently occurs in patients with asthma following bronchodilator administration (“volume responders”),47–51 supporting that reduced lung volume may be a manifestation of airway disease. The present study demonstrates that a similar physiologic pattern may be observed following WTC dust exposure.
Relating indices of inert gas washout to localised bronchoconstriction
2012, Respiratory Physiology and NeurobiologyCitation Excerpt :There is further potential for disconnect with Scond when units are so poorly ventilated that they do not communicate with the mouth, which is supported by the current model. Inert gas dilution is inaccurate in predicting the lung volumes of patients with severe asthma and airway closure (Woolcock and Read, 1966); it is theoretically possible that Scond has a similar disconnect to the severity of physiological impairment if the volume of trapped gas is significant. Table 3 lists estimates of FRC from the N2 washout simulations.
Functional Assessment of Asthma
2010, Pediatric Allergy: Principles and Practice Expert Consult: Second EditionMethacholine-induced pulmonary gas trapping in a mouse model of allergic asthma: Effect of inhaled budesonide and ciglitazone
2008, European Journal of Pharmacology
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This study was supported by a research fellowship and a grant in aid from the Asthma Foundation of New South Wales.
- 1
From the Department of Medicine, University of Sydney, and the Thoracic Unit, Royal Prince Alfred Hospital, Sydney, Australia.