Short communication
Effects of tachykinins on mucus secretion in human bronchi in vitro

https://doi.org/10.1016/0014-2999(89)90322-1Get rights and content

Abstract

We examined the effects of mammalian tachykinins on human bronchial secretion in vitro using fucose as an endogenous marker for mucus. Substance P (SP, 10−9–10−5 M) increased secretion in a dose-related manner and was more potent than neurokinin A or neurokinin B. The enkephalinase (endopeptidase 24.11) inhibitor phosphoramidon (10−5 M) potentiated the effect of SP (10−7 M). SP is a potent stimulant of secretion in human bronchi and enkephalinase may modulate its effects.

References (10)

There are more references available in the full text version of this article.

Cited by (109)

  • TRPV1 and neuropeptide receptor immunoreactivity and expression in the rat lung and brainstem after lung ischemia-reperfusion injury

    2016, Journal of Surgical Research
    Citation Excerpt :

    It has been shown that CGRP induces powerful vasodilation, particularly in the pulmonary artery.8 Meanwhile, SP release mediates contraction of airway smooth muscles,9 microvascular plasma leakage,10 and mucus secretion.11 Recently, a number of studies in rats and rabbits have shown activation of TRPV1 may protect against myocardial,12 pulmonary,13 hepatic,14 renal,15 and cerebral16 ischemia-reperfusion injury (IRI) by releasing neurotransmitters, in particular CGRP and SP.

  • Neural and humoral control of the airways

    2008, Asthma and COPD: Basic Mechanisms and Clinical Management
View all citing articles on Scopus
View full text