Clinical studyCoagulation factors, inflammation markers, and venous thromboembolism: the longitudinal investigation of thromboembolism etiology (LITE)☆
Section snippets
Study sample
The LITE study combined the established cohorts from the Cardiovascular Health Study (CHS) and the Atherosclerosis Risk In Communities (ARIC) study. The Cardiovascular Health Study examined the elderly (aged ≥65 years at entry) and ARIC examined adults aged 45 to 64 years 17, 18, 19. Information about cardiovascular risk factors was collected at the baseline examinations conducted from 1987 to 1989 in ARIC and from 1989 to 1990 in CHS. An additional cohort of 687 African Americans was recruited
Sample characteristics
A total of 159 incident cases of venous thromboembolism were ascertained (94 in ARIC, 65 in CHS) during 147,784 person-years of follow-up. The crude incidence rate per 1000 person-years was 0.80 in ARIC, 2.15 in CHS, and 1.08 in the combined cohort. Approximately half of the events had no obvious cause such as trauma or surgery.
Half of the participants who developed incident venous thromboembolism were women, and 72% were white (Table 1). Mean baseline levels of factor VII, factor VIII, and
Discussion
We found that levels of factor VIII, von Willebrand factor, and factor VII were positively and independently associated with the incidence of venous thromboembolism in this population-based cohort study. Hazard ratios tended to be larger in the middle-aged ARIC sample than in the older CHS sample. Fibrinogen and C-reactive protein levels, and white blood cell count—all markers of inflammation—were not associated with the incidence of venous thromboembolism.
Factor VIII has received much
Acknowledgements
The authors thank the staff and participants of CHS and the ARIC study for their important contributions over many years.
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The LITE study was funded by grant R01 HL59367 from the National Heart, Lung, and Blood Institute, Bethesda, Maryland. The Atherosclerosis Risk In Communities (ARIC) study was funded by contracts N01-HC-55015, N01-HC-55016, N01-HC-55018, N01-HC-55019, N01-HC-55020, N01-HC-55021, and N01-HC-55022 from the National Heart, Lung, and Blood Institute. The Cardiovascular Health Study (CHS) was funded by contracts N01-HC-85079 to N01-HC-85086 from the National Heart, Lung, and Blood Institute.