Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Volume 1833, Issue 12, December 2013, Pages 2823-2833
Connective tissue growth factor induces collagen I expression in human lung fibroblasts through the Rac1/MLK3/JNK/AP-1 pathway
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Graphical abstract
Abbreviations
AP-1
activator protein-1
ASK1
apoptosis signal-regulating kinase 1
c/EBPβ
CCAAT/enhancer-binding protein β
ChIP
chromatin immunoprecipitation
CTGF
connective tissue growth factor
ECM
extracellular matrix
ERK
extracellular signal-regulated kinase
FCS
fetal calf serum
IL-6
interleukin-6
JAK
Janus kinase
JNK
c-Jun N-terminal kinase
MAPKKK
MAPK kinase kinase
MAPKs
mitogen-activated protein kinases
MEM
Minimum Essential Medium
MLB
magnesium lysis buffer
MLK3
mixed-lineage kinase 3
NEAAs
non-essential amino acids
PBD
p21-binding domain
siRNA
small interfering RNA
α-SMA
α-smooth muscle actin
STAT
signal transducer and activator of transcription
TGF-β
transforming growth factor-β
WT
wild-type
Keywords
Connective tissue growth factor
Collagen I
Signal transduction
Lung fibrosis
Fibroblasts
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These authors contributed equally to this work.
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