Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor
Graphical abstract
Section snippets
Acknowledgement
The authors thank Dr. Nancy Delaet for her feedback on the content of this Letter.
References and notes (21)
- Experimental details on biochemical and cellular assays can be found in the Supplementary data...
- The JNK3 isoform was the only one available to us for crystallography during this drug discovery...
- et al.
Bioorg. Med. Chem. Lett.
(2002) - et al.
Inflamm. Allergy: Drug Targets
(2010)et al.Expert Opin. Invest. Drugs
(2010)Nat. Rev. Drug Discov.
(2010) - et al.
Am. J. Respir. Crit. Care Med.
(2011) - Plantevin Krenitsky, V.; Nadolny, L.; Sahasrabudhe, K.; Ayala, L.; Delgado, M.; Clareen, S.; Hilgraf, R.; Albers, R.;...
- et al.
Curr. Enz. Inhib.
(2010) - et al.
Br. J. Pharmacol.
(2003)et al.J. Pharmacol. Exp. Ther.
(2009)et al.Gastroenterology
(2010)et al.Circulation
(2011)et al.J. Pathol.
(2007) - et al.
J. Med. Chem.
(2010)
There are more references available in the full text version of this article.
Cited by (0)
Copyright © 2011 Elsevier Ltd. All rights reserved.