Original StudyRelationship Between Vitamin D Status and ICU Outcomes in Veterans
Section snippets
Methods
The study was conducted at a veterans Affairs (VA) facility in the Southeastern United States. The Research and Development Committee at the VA Medical Center and the Institutional Review Board at the affiliated university approved the study. Data were obtained electronically through retrospective medical record review after personal information was redacted. The study group included all patients admitted to the ICU over a 10-year period (October 1, 1999 to October 1, 2009) with a serum
Results
A total of 136 patients with reported vitamin D levels were identified: 42 admitted to the surgical intensive care unit (SICU) and 94 admitted to the medical intensive care unit (MICU). As MICU and SICU patients did not differ significantly with regard to vitamin D level or deficiency status (P > .05), further analyses combined the 2 groups for a total of 136 patients. Of the 136 patients, 50 (37%) had vitamin D levels checked before admission, whereas the remainder had vitamin D levels
Discussion
Vitamin D deficiency was associated with increased length of stay and mortality among veterans admitted to ICU. Vitamin D deficiency can be associated with self-neglect in the elderly.19 It is possible that vitamin D deficiency at the onset of acute illness may contribute to less than optimal outcomes and may add to the protracted recovery seen in some of these patients.20
Jeng et al15 demonstrated that critical illness was associated with lower 25(OH)D levels. The lower albumin levels seen in
Acknowledgments
The assistance of Perry Jackson and Patsy Ellis, Medical Library at Mountain Home VAMC, and Dr Joy Wachs, East Tennessee State University College of Nursing, are gratefully acknowledged.
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The effect of vitamin D supplementation on inflammation in critically ill patients: A systematic review
2020, PharmaNutritionCitation Excerpt :Based on the current data, calcitriol is suggested to modulate cytokine production, and decrease infection and mortality rate [5,26,28,29]. Observational studies have demonstrated an inverse association between low serum calcidiol levels and higher rates of mortality and adverse clinical consequences in critically ill patients [30–32]. High doses of vitamin D administration could promote lymphocyte T and dendritic cell differentiation, inhibit cell proliferation and the genes encoding pro-inflammatory cytokines (e.g., IL-1 and TNF) [33–35].
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This material is the result of work supported with resources and the use of facilities at Mountain Home VA Medical Center in Johnson City, Tennessee. The contents of this paper do not represent the views of the Department of Veterans Affairs or the US government.