Elsevier

Respiratory Medicine

Volume 103, Issue 12, December 2009, Pages 1796-1800
Respiratory Medicine

The role of EBUS-TBNA for the diagnosis of sarcoidosis – comparisons with other bronchoscopic diagnostic modalities

https://doi.org/10.1016/j.rmed.2009.07.013Get rights and content
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Summary

Background

The diagnosis of sarcoidosis requires both compatible clinical features and pathologic findings as a means to exclude other differential diagnoses. The utility of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for diagnosis of sarcoidosis has been reported, although its indication remains unclear for cases of suspicious sarcoidosis. To clarify the role of EBUS-TBNA for the diagnosis of sarcoidosis, we compared three diagnostic modalities: EBUS-TBNA, transbronchial lung biopsy (TBLB) and bronchoalveolar lavage fluid analysis (BAL).

Methods

Thirty-eight patients with suspicious sarcoidosis who had enlarged hilar and/or mediastinal lymph nodes on chest CT were retrospectively reviewed. Patients with malignancies or prior established diagnosis of sarcoidosis were excluded. BAL was initially performed followed by TBLB and finally EBUS-TBNA at the same setting. Microbacterial examinations were also performed from all samples.

Results

Pathological findings compatible with sarcoidosis were obtained in 32 patients. The remaining 6 patients were diagnosed as one case each of chronic eosinophilic pneumonia, atypical mycobacterial infection and tuberculosis, and the remaining three were pathologically indefinite cases. Clinically, 35 patients were diagnosed with sarcoidosis. The diagnostic accuracy of sarcoidosis was significantly better by EBUS-TBNA (91.4%, p < 0.001) compared to the other two modalities. According to chest roentgenogram classifications, there were 31 stage I patients and 4 stage II patients. For stage I patients, EBUS-TBNA was significantly better (90.3%, p < 0.001), but each modality showed 100% accuracy for stage II patients.

Conclusion

It is recommended that EBUS-TBNA is added to the conventional diagnostic modalities for patients with suspicious stage I sarcoidosis on chest roentgenogram.

Keywords

Bronchoscopy
Bronchoalveolar lavage fluid
Diagnostic procedures
Endobronchial ultrasound
Sarcoidosis and other granulomatosis
Transbronchial lung biopsy

Abbreviations

BAL
bronchoalveolar lavage fluid analysis
CT
computed tomography
EBUS-TBNA
endobronchial ultrasound-guided transbronchial needle aspiration
TBLB
transbronchial lung biopsy
EUS-FNA
endoscopic ultrasound-guided fine needle aspiration

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