Original Articles: Allergy, Rhinitis, Other Respiratory DiseasesEthnic differences in asthma and associated phenotypes: Collaborative Study on the Genetics of Asthma☆,☆☆
Section snippets
Study populations
Subjects with asthma were evaluated at 4 centers chosen to participate in the CSGA. The Johns Hopkins University (center 1) studied an urban Baltimore population and an inner-city population from Washington, DC, in collaboration with Howard University; the University of Chicago (center 2) studied Chicago inner-city and suburban families; the University of Minnesota (center 3) studied large, multigenerational families; and the University of Maryland (center 4) studied an urban Baltimore
Results
A total of 2584 individuals from 314 families were evaluated during the 3-year period of active recruitment (1993-1996). The mean family size was 8.2; centers 1, 2, and 4 predominantly studied small nuclear families (mean size = 6.5), and center 3 studied 22 large, multigenerational families (mean family size, 32.3). The sample was 46% white, 41% African American, and 13% Hispanic.
Discussion
Asthma is a disorder characterized by airway inflammation, reversible airflow obstruction, and bronchial hyperresponsiveness (BHR) to a variety of allergic and other environmental stimuli. A genetic component for asthma has been suggested from a variety of family and epidemiologic studies.1 Genome-wide searches and candidate gene approaches have identified many genes and regions that potentially influence asthma susceptibility or asthma severity.2, 11, 12, 13, 14, 15, 16, 17, 18 The CSGA has
Acknowledgements
We acknowledge Terri Beaty, Kathleen Barnes, Nancy Cox, and Susan-Banks Schlegel for helpful discussions regarding this manuscript, and Rhonda Peterson, Jennifer Anderson, Heidi Gidley (University of Chicago), Betsy Rechtsteiner, Shannon Gierczak, Adam Boldt (University of Maryland), Galena Maslennikova, Doris Bowling (University of New Mexico) (Shirley), Marion Stochton, Paulette Ferbert-Harris (Johns Hopkins University), and Delores Drury (University of Minnesota) for day-to-day coordination
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Supported by U01 HL/AI 49612 (JHU), UO1 HL/AI49596 (UC), HL/AI 49609, M01-RR00400 (UMN), U01 HL/AI49602 (UMD), HRRC 93-196 (UNM), UO1 HL 58977 (WFU), and MR1 RR00055 (UC).
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Reprint requests: Eugene R. Bleecker, MD, Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157.