Chest
Original ResearchPulmonary ProceduresDiagnostic Yield of Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration: Results of the AQuIRE Bronchoscopy Registry
Section snippets
Materials and Methods
All patients undergoing bronchoscopy with LN sampling by TBNA biopsy were entered consecutively into the registry from February 13, 2009, to February 28, 2010. Institutional review board approval was obtained at each participating site, and informed consent or a waiver of consent was obtained according to institutional guidelines. All data were entered via a Web-based interface.16 Since this is a registry, all clinical decisions, including type of TBNA used (conventional vs EBUS), were left to
Results
Six hospitals with 11 physicians enrolled 891 patients. Baseline demographics, clinical characteristics, and procedural details are shown in Table 1, and diagnoses are shown in Table 2. EBUS-TBNA was used in 95% of the cases, and conventional TBNA was used in the other 5%. The most common diagnosis was malignancy, followed by sarcoidosis. The percentage of cases with a malignant diagnosis did not significantly differ among hospitals (P = .16). A specific diagnosis was made by TBNA biopsy in 447
Discussion
To our knowledge, this is the first prospective study of risk-adjusted diagnostic yield for EBUS-TBNA biopsy using multicenter registry data. Our findings suggest that diagnostic yield varies significantly among hospitals and is driven by patient- and hospital-level variables. Patient-level variables such as LN size have been identified previously, but this is the first prospective study to demonstrate a relationship between hospital TBNA biopsy volume and diagnostic yield.
The effect of
Acknowledgments
Author contributions: Dr Ost: contributed to registry design and organization, data collection and auditing, statistical analyses, and manuscript writing and was principal investigator for this study.
Dr Ernst: contributed to the study design, registry organization, and manuscript writing.
Dr Lei: contributed to constructing the multilevel models and analyses, manuscript writing, and was the primary biostatistician for the project.
Dr Feller-Kopman: contributed to the data collection, study
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Funding/Support: The American College of Chest Physicians (ACCP) funded database construction for the AQuIRE program. The data used for this publication was provided through The ACCP AQuIRE Registry.
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