Chest
Original ResearchSigns and Symptoms of Chest DiseaseFour-Hour Cough Frequency Monitoring in Chronic Cough
Section snippets
Subjects
One hundred consecutive patients with chronic cough were recruited from a general respiratory clinic that receives > 80% of its referrals from primary care. All patients presented with an isolated chronic cough. Chronic cough was defined as a cough lasting > 8 weeks duration. The cause of cough in all patients was ascertained from case note review when investigation and treatment trials were complete. All patients were assessed using a standardized diagnostic protocol.10 A diagnosis was
Results
One hundred patients with chronic cough were recruited. The primary causes of cough were asthma (n = 24), eosinophilic bronchitis (n = 7), rhinitis (n = 9), GERD (n = 3), idiopathic chronic cough (n = 29), postviral cough (n = 7), sarcoidosis (n = 6), interstitial lung disease (n = 8), obstructive sleep apnea (n = 2), bronchiectasis (n = 2), chronic bronchitis (n = 1), angiotensin-converting enzyme inhibitor-induced (n = 1), and postinfective (n = 1)). Baseline characteristics are shown in
Discussion
To our knowledge, this is the first study to investigate cough frequency measurement with short cough-monitor recordings in patients with chronic cough. There was good agreement between 4-h and 24-h cough recordings. Both CF4 and CF24 were associated with subjective measures of cough severity. Four-hour recordings were responsive, suggesting they could be used to assess the efficacy of therapeutic trials.
Cough monitors are usually set to record for 24 h. We hypothesized that short daytime
Acknowledgments
Author contributions: Dr Birring is guarantor of the manuscript.
Dr Lee: contributed to study concept and design; acquisition, analysis, and interpretation of data; and drafting of the manuscript for important intellectual content.
Dr Savani: contributed to acquisition of data and drafting of the manuscript for important intellectual content.
Dr Matos: contributed to analysis and interpretation of data and drafting of the manuscript for important intellectual content.
Dr Evans: contributed to
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Funding/Support: This study was funded by the King's College Hospital NHS Foundation Trust.
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