Chest
Laboratory and Animal InvestigationsThe Role of Neutrophils in the Pathogenesis of Idiopathic Pulmonary Fibrosis
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Subjects
The protocols of this study were approved by the institutional review board for human studies, and informed written consent was obtained from the subjects.
A diagnosis of IPF required the following:12,13 (1) no clinical history of exposure to environmental agents known to cause interstitial lung disease, no history suggestive of extrinsic allergic alveolitis, and no history of chronic lung infection or left ventricular failure; (2) evidence of interstitial infiltrates on chest radiograph or
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2023, Respiratory Medicine Case ReportsHigher susceptibility of males to bleomycin-induced pulmonary inflammation is associated with sex-specific transcriptomic differences in myeloid cells
2022, Toxicology and Applied PharmacologyCitation Excerpt :Neutrophil increase in the bronchoalveolar lavage (BAL) fluid is associated with early mortality in IPF (Kinder et al., 2008). Similarly, neutrophil elastase is increased in the BAL fluid and sera of IPF patients (Obayashi et al., 1997) and neutrophil elastase deficient mice are protected from fibrosis in bleomycin model indicating a critical role of neutrophils in IPF (Chua et al., 2007). Macrophages are the cell-type that has been extensively studied in IPF (Desai et al., 2018).
Polyhexamethylene guanidine phosphate-induced necrosis may be linked to pulmonary fibrosis
2022, Toxicology LettersPrognostic significance of peripheral blood monocyte and neutrophil counts in rheumatoid arthritis-associated interstitial lung disease
2021, Respiratory MedicineCitation Excerpt :Neutrophil elastase accelerated pulmonary fibrosis by promoting fibroblast proliferation and myofibroblast differentiation in mice [22]. Obayashi et al. reported that the levels of neutrophil elastase in serum and bronchoalveolar lavage fluid of patients with IPF were higher than those of healthy subjects, suggesting its involvement in developing IPF [19]. These findings suggest that increased neutrophil numbers may participate in the pathogenesis of fibrotic ILD.
A proposed role of neutrophil extracellular traps and their interplay with fibroblasts in ANCA-associated vasculitis lung fibrosis
2021, Autoimmunity ReviewsCitation Excerpt :As different ECM molecules have been reported as substrates for NE (collagen, fibronectin, laminin), it is not surprising to find NE associated with disorders where ECM degradation is the hallmark, such as pulmonary emphysema [77,78]. Paradoxically, the role of NE has also been associated with diseases characterised by ECM deposition such as ILD; studies have found increased levels of NE, NE degradation products or inhibitors in BAL from such patients [79–81]. Although the NE effect was almost exclusively associated with the TGF-β activation derived from collagen degradation, other mechanisms have been recently described.
Proportions of resting memory T cells and monocytes in blood have prognostic significance in idiopathic pulmonary fibrosis
2019, GenomicsCitation Excerpt :Our study also suggested neutrophils as another detrimental cell type for IPF as a higher proportion of neutrophils in the blood was associated with a lower survival rate (Fig. 4). The detrimental role of neutrophils in IPF was suggested by a study, where high levels of neutrophil elastase were detected in the lung parenchyma and also in both the BALF (bronchoalveolar lavage fluid) and sera [14]. Considerable numbers of neutrophils were also shown to infiltrate the lung parenchyma according to immunohistochemistry [14].
Reprint requests: Jiro Fujita, MD, First Department of Internal Medicine, Kagawa Medical School, 1750-1, Miki-cho, Kita-gun, Kagawa, 761-07, Japan