Chest
Clinical Investigations: Sleep and BreathingTissue Hypoxia in Sleep Apnea Syndrome Assessed by Uric Acid and Adenosine
Section snippets
Subjects
Eighteen adult male subjects with OSAS diagnosed by standard polysomnography were recruited for this study. Inclusion criteria of subjects for this study were as follows: the apnea-hypopnea index (AHI) was > 15/h, the minimum Sao2 was < 80%, and the percentage of time with Sao2 < 90% was > 5%. We excluded the subjects who had gout, diabetes mellitus requiring medication, and renal dysfunction assessed by the serum level of creatinine.
Of 18 subjects, 4 subjects had diabetes mellitus that was
Results
The value of ΔUA/Cr in the 18 subjects widely varied from − 60.8 to 58.3% (mean, − 6.1 ŷ 7.5%). Of them, nine subjects were classified into the ΔUA/Cr-positive group, and the other nine subjects were classified into the normal group (Fig 2). The data obtained from 12 control subjects are also illustrated as individual mean values in Figure 2.
There were no significant differences between the two groups in age, body mass index, and the plasma level of uric acid. Unexpectedly, there were no
Discussion
In this study, we demonstrated that the index of ΔUA/Cr did not parallel the severity of the AI or arterial oxygen desaturation, but was significantly linked to the plasma level of adenosine, which is considered to be another marker of tissue hypoxia, in patients with OSAS. These data indicate that both indexes of ΔUA/Cr and plasma adenosine during sleep reflect the same purine catabolic pathway associated with tissue hypoxia in these patients. We further demonstrated that the intersubject
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This study was supported by Research Grant for the Intractable Diseases from the Ministry of Health and Welfare, Japan, and Science Research grant No. 04670451 from the Ministry of Education, Science, Sports and Culture, Japan.
Dilazep was a gift of Kowa Co. Ltd.