Chest
Clinical InvestigationsEXERCISEAltered Exercise Gas Exchange as Related to Microalbuminuria in Type 2 Diabetic Patients
Section snippets
Subject Recruitment
From November 2000 to June 2002, three categories of subjects were recruited from Pamela Youde Nethersole Eastern Hospital, Hong Kong: (1) type 2 diabetic patients with normoalbuminuria (defined as daily urinary albumin excretion [UAE] < 30 mg/d), (2) type 2 diabetic patients with microalbuminuria (defined as daily UAE of 30 to 300 mg/d), and (3) normal control subjects. The latter were volunteers free of diabetes mellitus, and were recruited from among the hospital staff. Subjects of both
Results
Twenty patients were recruited into each of the three groups: control, normoalbuminuria, and microalbuminuria. Their baseline characteristics are shown in Table 1. There were no statistical differences among the three groups for age, body weight, and height. The three groups also had similar resting lung function (Table 2).
Exercise testing parameters are shown in Table 3. All subjects exercised until exhaustion. All stopped exercise because of leg fatigue or generalized weakness, none because
Discussion
Our findings confirmed that cardiopulmonary abnormalities were present in type 2 diabetic patients during exercise, and the severity of some of these abnormalities were correlated with the level of microalbuminuria. Impaired exercise capacity in terms of peak o2 or WR has been documented in both type 1 diabetes711131415 and type 2 diabetes16 to be related to longstanding disease,11 higher total glycosylated hemoglobin A1,14 higher body mass index, female sex, older age, higher resting systolic
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2009, Journal of Diabetes and its ComplicationsCitation Excerpt :Future research will determine the duration, type, intensity and frequency of regular exercise which is required to induce beneficial alterations in hemostatic markers. To our knowledge, there is only one study evaluating the influence of exercise on UAE (Lau et al., 2004). In our study we confirmed that exercise capacity was inversely associated with UAE.
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2007, Diabetes Research and Clinical PracticeCitation Excerpt :The observed LT values were 0.97 ± 0.27 l O2 min−1[27] and 13.5 ± 1.9 ml O2 kg−1 min−1[34]. These differences may be related to pathological complications, insulin [33,36] and antihypertensive use [35,36] and higher fasting glucose values (188–215 mg/dl) [27,34,35] presented by the patients of cited studies, indicating a more advanced pathological condition when compared to our volunteers. Moreover, cycle ergometer exercise was employed in most studies [27,33,35,36].
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This work was performed at the Departments of Medicine and Nuclear Medicine, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China.
All expenses were supported by the Department of Medicine, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China.