Chest
Clinical InvestigationsPrognostic Value of the Hematocrit in Patients With Severe COPD Receiving Long-term Oxygen Therapy
Section snippets
Organization of the ANTADIR Observatory
The ANTADIR is a French national nonprofit associative network of 23 regional associations founded in 1981 to ensure health-care support and technical follow-up to disabled patients requiring domiciliary oxygen support, mechanical ventilation, or continuous positive airway pressure. Since its foundation, ANTADIR has maintained a comprehensive demographic database or “observatory,”14 providing a unique national register allowing epidemiologic surveys in large cohorts of patients with various
Hematocrit
Anemia can be defined by a hematocrit < 39% in men and < 36% in women.17 According to this definition, the prevalence of anemia in the cohort studied was 12.6% in men and 8.2% in women (but 18.5% of the women had a hematocrit < 39%). The prevalence of a hematocrit value ≥ 55% was 8.4% (men, 8.9%; women, 5.9%). Hematocrit was significantly higher in men than in women (t = 5.6, p < 0.001), and was negatively correlated with age (r = −0.245, p < 0.001) and positively correlated with Paco2 (r =
Discussion
This study shows that in a large population of COPD patients treated with LTOT, the prevalence of a low hematocrit at the time the prescription of oxygen is far from negligible (12.6% of the men and 18.5% of the women meeting the World Health Organization definition of anemia [hematocrit < 39%]17). In this particular population, the study also points to a strong association between hematocrit and long-term survival in this population.
These findings seem to contrast with commonly held views.
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Dr. Chambellan was supported by a grant from the Association Regionale de l’Insuffisance Respiratoire des Pays de la Loire.
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/misc/reprints.shtml).