Original ArticlePrimary Pulmonary Carcinoma in Patients With Idiopathic Pulmonary Fibrosis
Section snippets
PATIENTS AND METHODS
Our study group consisted of 24 patients with both histologically proven UIP and primary lung carcinoma. Patients were identified through a retrospective computerized search of the Rochester Mayo Clinic database for 1990 to 1998. Patients with connective tissue disease, asbestos exposure, previous radiation therapy, or metastatic disease to the lung were excluded. Patients taking drugs that could potentially induce pulmonary fibrosis were also excluded. Thus, study patients were considered to
Clinical Findings
Clinical findings in the 24 patients with IPF and carcinoma are detailed in Table 1. The study group was composed of 21 men and 3 women, with a mean age of 72.3 years. Twenty were past and 2 were current cigarette smokers, with mean exposures of 53.5 pack-years (range, 10-105 pack-years). Sixteen patients (67%) had IPF and carcinoma diagnosed within 4 months of one another. In 6 of these, both diagnoses were made during the same evaluation. In 7, the diagnosis of carcinoma followed the
DISCUSSION
Carcinoma arising in association with IPF appears to be more common in men than women. The male predominance in our study parallels that seen in other reports of lung carcinoma developing in patients with IPF or other types of chronic interstitial fibrosis. In a review of 4 published series1, 11, 12, 21 describing a total of nearly 150 patients, men outnumbered women by a ratio of more than 10:1. This greatly exceeds the male-female ratio generally observed in IPF22 or primary lung carcinoma
Acknowledgments
We thank Jennifer A. Besse for her assistance with statistics in this study.
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Dr Washington Stephens is now with The University of Texas M. D. Anderson Cancer Center, Houston