Abstract
We conducted a trial of oral acetazolamide for the treatment of cryptococcal meningitis in 22 Thai adults with headache and an opening cerebrospinal fluid pressure of >/=200 mm H(2)0. The trial was terminated prematurely because patients who received acetazolamide developed significantly lower venous bicarbonate levels and higher chloride levels and had more-frequent serious adverse events than did subjects who received placebo.
Publication types
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Clinical Trial
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetazolamide / therapeutic use*
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Acidosis / etiology
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Administration, Oral
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Adult
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Amphotericin B / therapeutic use
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Antifungal Agents / therapeutic use
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Diuretics / therapeutic use
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Double-Blind Method
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Female
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Headache / drug therapy
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Humans
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Hypokalemia / etiology
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Intracranial Hypertension / drug therapy*
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Intracranial Hypertension / etiology
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Male
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Meningitis, Cryptococcal / complications*
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Meningitis, Cryptococcal / drug therapy
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Middle Aged
Substances
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Antifungal Agents
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Diuretics
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Amphotericin B
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Acetazolamide