Abstract
Lung transplantation is complicated by fibroproliferation, which is likely mediated in part by matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs. This commentary briefly discusses what is known about these mediators in fibrotic pulmonary diseases and how an important new study by Yoshida and colleagues sheds light on the diverse functions of these proteins in alloimmune inflammation.
MeSH terms
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Autoimmunity / physiology*
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Graft Rejection / etiology
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Graft Rejection / immunology
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Humans
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Lung Transplantation / immunology*
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Matrix Metalloproteinase Inhibitors
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Matrix Metalloproteinases / physiology*
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Pneumonia / immunology
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Pneumonia / physiopathology
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Pulmonary Fibrosis / immunology
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Pulmonary Fibrosis / physiopathology*
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Tissue Inhibitor of Metalloproteinases / physiology
Substances
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Matrix Metalloproteinase Inhibitors
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Tissue Inhibitor of Metalloproteinases
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Matrix Metalloproteinases