Abstract
The objective of this study was to observe the prevalence of drug resistance in Mycobacterium tuberculosis isolates in HIV associated tuberculosis co-infected patients in Phnom Penh City. The isolates of M. tuberculosis were collected during active laboratory-based surveillance. Of the 98 isolates studied, M. tuberculosis resistance to isoniazid was seen in 23.5%, resistance to rifampicin was seen in 16.3% and multidrug-resistance (MDR-TB) was seen in 5.1%. Our findings reveal an alarmingly high level of resistance to isoniazid and rifampicin, and confirms the need for drug susceptibility testing to guide treatment in patients with culture positive tuberculosis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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AIDS-Related Opportunistic Infections / complications
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AIDS-Related Opportunistic Infections / epidemiology*
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Antitubercular Agents / therapeutic use*
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Cambodia / epidemiology
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HIV Infections / complications
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HIV Infections / epidemiology*
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HIV Seropositivity / complications
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HIV Seropositivity / epidemiology
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HIV-1
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Humans
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Isoniazid / therapeutic use
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Microbial Sensitivity Tests
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Mycobacterium tuberculosis / drug effects
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Mycobacterium tuberculosis / isolation & purification*
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Prevalence
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Rifampin / therapeutic use
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Risk Factors
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Streptomycin / therapeutic use
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Tuberculosis, Multidrug-Resistant / epidemiology*
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Tuberculosis, Pulmonary / complications
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Tuberculosis, Pulmonary / drug therapy*
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Tuberculosis, Pulmonary / microbiology
Substances
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Antitubercular Agents
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Isoniazid
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Rifampin
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Streptomycin