Abstract
Numerous epidemiological studies have consistently linked the presence of chronic obstructive pulmonary disease (COPD) to the development of lung cancer, independently of cigarette smoking dosage. The mechanistic explanation for this remains poorly understood. Progress towards uncovering this link has been hampered by the heterogeneous nature of the two disorders: each is characterized by multiple sub-phenotypes of disease. In this Review, I discuss the nature of the link between the two diseases and consider specific mechanisms that operate in both COPD and lung cancer, some of which might represent either chemopreventive or chemotherapeutic targets.
MeSH terms
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Carcinoma, Non-Small-Cell Lung / epidemiology*
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Carcinoma, Non-Small-Cell Lung / etiology
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Carcinoma, Non-Small-Cell Lung / physiopathology
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Genetic Predisposition to Disease
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Humans
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Inflammation / epidemiology
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Inflammation / physiopathology
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Lung Neoplasms / epidemiology*
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Lung Neoplasms / etiology
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Lung Neoplasms / physiopathology
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Oxidative Stress
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Pulmonary Disease, Chronic Obstructive / complications
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Pulmonary Disease, Chronic Obstructive / epidemiology*
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Pulmonary Disease, Chronic Obstructive / genetics
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Pulmonary Disease, Chronic Obstructive / physiopathology
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Pulmonary Emphysema / complications
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Small Cell Lung Carcinoma / epidemiology*
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Small Cell Lung Carcinoma / etiology
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Small Cell Lung Carcinoma / physiopathology