Abstract
Neutrophil motility and superoxide anion production and serum immunoglobulin levels were assessed in 51 children with recurrent infections of the lower respiratory tract and chronic bronchial suppuration, not due to anatomic or functional cause. In 26 children (50.9%), a significant defect of the immunologic defenses, likely to be responsible for the disease, was observed. A precocious diagnosis and an adequate therapy could result, at least in some patients, in the prevention of progressive lung damage.
MeSH terms
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Adolescent
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Adult
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Antibodies, Bacterial / biosynthesis*
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Bacterial Infections / blood
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Bacterial Infections / immunology*
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Bronchiectasis / blood
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Bronchiectasis / immunology*
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Bronchopneumonia / blood
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Bronchopneumonia / immunology*
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Cell Movement
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Child
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Child, Preschool
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Chronic Disease
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Female
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Humans
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Immunoglobulin A / biosynthesis
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Immunoglobulin E / biosynthesis
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Immunoglobulin G / biosynthesis
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Immunoglobulin M / biosynthesis
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Leukocyte Count
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Male
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Neutrophils / immunology*
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Neutrophils / pathology
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Recurrence
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Suppuration / blood
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Suppuration / immunology
Substances
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Antibodies, Bacterial
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Immunoglobulin A
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Immunoglobulin G
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Immunoglobulin M
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Immunoglobulin E