Successful treatment of sclerosing cervicitis and fibrosing mediastinitis with tamoxifen

B A Savelli; M Parshley; M L Morganroth

doi:10.1378/chest.111.4.1137

Successful treatment of sclerosing cervicitis and fibrosing mediastinitis with tamoxifen

Chest. 1997 Apr;111(4):1137-40. doi: 10.1378/chest.111.4.1137.

Authors

B A Savelli¹, M Parshley, M L Morganroth

Affiliation

¹ Providence Medical Center, Department of Medical Education, Oregon Health Sciences University, Portland, USA.

PMID: 9106605
DOI: 10.1378/chest.111.4.1137

Abstract

Fibrosing mediastinitis and sclerosing cervicitis are fibrosclerotic disorders akin to retroperitoneal fibrosis, with presenting symptoms related to local pain or viscus obstruction or both. No definitive treatment is known. This is the first report of these disorders dramatically responding to tamoxifen citrate and prednisone.

Publication types

Case Reports

MeSH terms

Adult
Anticarcinogenic Agents / administration & dosage
Anticarcinogenic Agents / therapeutic use*
Female
Fibrosis
Humans
Mediastinitis / drug therapy*
Neck / pathology*
Prednisone / administration & dosage
Sclerosis
Tamoxifen / administration & dosage
Tamoxifen / therapeutic use*

Substances

Anticarcinogenic Agents
Tamoxifen
Prednisone