In countries with the best cancer outcomes, approximately 60% of patients receive
radiotherapy as part of their treatment, which is one of the most cost-effective cancer …

In adults, primary malignant brain tumors (PMBT) are rare, but they have a devastating
impact and the chances for survival are limited. UK clinical guidance on supportive care for …

The diagnosis and management of high-grade glioma has profound effects on patients and
their families. Guidance issued by the UK National Institute of Health and Clinical Excellence …

A network of communicating tumour cells that is connected by tumour microtubes mediates
the progression of incurable gliomas. Moreover, neuronal activity can foster malignant …

Abstract l-Glutamine (Gln) functions physiologically to balance the carbon and nitrogen
requirements of tissues. It has been proposed that in cancer cells undergoing aerobic …

During apoptosis, the mitochondrial outer membrane is permeabilized, leading to the
release of cytochrome c that activates downstream caspases. Mitochondrial outer …

Background and purpose Target delineation in glioblastoma (GBM) varies substantially
between different institutions and several consensus statements are available. This …

ADAPTeR is a prospective, phase II study of nivolumab (anti-PD-1) in 15 treatment-naive
patients (115 multiregion tumor samples) with metastatic clear cell renal cell carcinoma …

PURPOSE: Current treatments for glioblastoma multiforme are inadequate and limited by
the radiation sensitivity of normal brain. Because glioblastoma multiforme are rapidly …

Glioblastoma is the most common form of primary brain tumor in adults and is essentially
incurable. Despite aggressive treatment regimens centered on radiotherapy, tumor …