The role of the tumor-microenvironment in lung cancer-metastasis and its relationship to potential therapeutic targets
SL Wood, M Pernemalm, PA Crosbie… - Cancer treatment …, 2014 - Elsevier
Non-small cell lung cancer (NSCLC) accounts for> 80% of lung cancer cases and currently
has an overall five-year survival rate of only 15%. Patients presenting with advanced stage …
has an overall five-year survival rate of only 15%. Patients presenting with advanced stage …
Homing and mobilization in the stem cell niche
AD Whetton, GJ Graham - Trends in cell biology, 1999 - cell.com
All mature blood cells are derived from the haemopoietic stem cell (HSC). In common with
all other haemopoietic cells, stem cells are mobile, and it is this property of mobility that has …
all other haemopoietic cells, stem cells are mobile, and it is this property of mobility that has …
Molecular histology of lung cancer: from targets to treatments
SL Wood, M Pernemalm, PA Crosbie… - Cancer treatment …, 2015 - Elsevier
Lung cancer is the leading cause of cancer-related death worldwide with a 5-year survival
rate of less than 15%, despite significant advances in both diagnostic and therapeutic …
rate of less than 15%, despite significant advances in both diagnostic and therapeutic …
[HTML][HTML] Eight-channel iTRAQ enables comparison of the activity of six leukemogenic tyrosine kinases
There are a number of leukemogenic protein-tyrosine kinases (PTKs) associated with
leukemic transformation. Although each is linked with a specific disease their functional …
leukemic transformation. Although each is linked with a specific disease their functional …
Systems-level dynamic analyses of fate change in murine embryonic stem cells
Molecular regulation of embryonic stem cell (ESC) fate involves a coordinated interaction
between epigenetic,,,, transcriptional,,,,, and translational, mechanisms. It is unclear how …
between epigenetic,,,, transcriptional,,,,, and translational, mechanisms. It is unclear how …
Simultaneous analysis of relative protein expression levels across multiple samples using iTRAQ isobaric tags with 2D nano LC–MS/MS
In this paper, we describe the use of iTRAQ (isobaric Tags for Relative and Absolute
Quantitation) tags for comparison of protein expression levels between multiple samples …
Quantitation) tags for comparison of protein expression levels between multiple samples …
Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells
Chronic myeloid leukaemia (CML) arises after transformation of a haemopoietic stem cell
(HSC) by the protein-tyrosine kinase BCR–ABL. Direct inhibition of BCR–ABL kinase has …
(HSC) by the protein-tyrosine kinase BCR–ABL. Direct inhibition of BCR–ABL kinase has …
[HTML][HTML] Multiple reaction monitoring to identify sites of protein phosphorylation with high sensitivity* S
Phosphorylation governs the activity of many proteins. Insight into molecular mechanisms in
biology would be immensely improved by robust, sensitive methods for identifying precisely …
biology would be immensely improved by robust, sensitive methods for identifying precisely …
Quantitative proteomics reveals posttranslational control as a regulatory factor in primary hematopoietic stem cells
RD Unwin, DL Smith, D Blinco, CL Wilson, CJ Miller… - Blood, 2006 - ashpublications.org
The proteome is determined by rates of transcription, translation, and protein turnover.
Definition of stem cell populations therefore requires a stem cell proteome signature …
Definition of stem cell populations therefore requires a stem cell proteome signature …
[PDF][PDF] Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling
Many signals must be integrated to maintain self-renewal and pluripotency in embryonic
stem cells (ESCs) and to enable induced pluripotent stem cell (iPSC) reprogramming …
stem cells (ESCs) and to enable induced pluripotent stem cell (iPSC) reprogramming …