Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance
regulator (CFTR), which lead to early death due to progressive lung disease. The …

The present study provides molecular and functional characterization of Na+-K+-2Cl−
cotransporter (NKCC1/Slc12a2) in the gills of sea lamprey (Petromyzon marinus), the most …

It is unknown whether and how osmoregulation is controlled by corticosteroid signaling in
the phylogenetically basal vertebrate group Agnatha, including lampreys and hagfishes. It is …

Although corticosteroid-mediated hepatic gluconeogenic activity in response to stress has
been extensively studied in fishes and other vertebrates, there is little information on the …

Lampreys are the most basal vertebrates with an osmoregulatory strategy. Previous
research has established that the salinity tolerance of sea lamprey increases dramatically …

Abstract Chronic type 2 (T2) inflammatory diseases of the respiratory tract are characterized
by mucus overproduction and disordered mucociliary function, which are largely attributed to …

To understand the mechanism for activation of the melanocortin-2 receptor (Mc2r) of the
elasmobranch, Rhincodon typus (whale shark; ws), wsmc2r was co-expressed with …

With remarkably few exceptions, aquatic vertebrates maintain internal Cl− homeostasis
despite strong and sometimes fluctuating Cl− concentration gradients between extracellular …

In bony vertebrates, melanocortin 2 receptor (Mc2r) specifically binds adrenocorticotropic
hormone (ACTH) and is responsible for mediating anterior pituitary signaling that stimulates …

The hypothalamus–pituitary–adrenal/interrenal (HPA/I) axis is a conserved vertebrate
neuroendocrine mechanism regulating the stress response. The penultimate step of the …