Chronic obstructive pulmonary disease (COPD) is a progressive disease that begins many
years before a diagnosis is usually made. The need for an early and confirmed diagnosis of …

Educational Aims To improve understanding of: The relative benefits and limitations of
evidence derived from different study designs and the role that real-life asthma studies can …

The British Thoracic Society (BTS) Home Oxygen Guideline provides detailed evidence-
based guidance for the use of home oxygen for patients out of hospital. Although the …

Background Most randomized trials of treatment for asthma study highly selected patients
under idealized conditions. Methods We conducted two parallel, multicenter, pragmatic trials …

Background: Many patients with obstructive lung disease (OLD) carry an inaccurate
diagnostic label. Symptom-based questionnaires could identify persons likely to need …

Background: Symptom-based questionnaires may enhance chronic obstructive pulmonary
disease (COPD) screening in primary care. Objectives: We prospectively tested questions to …

Background Patterns of health-care use and comorbidities present in patients in the period
before diagnosis of chronic obstructive pulmonary disease (COPD) are unknown. We …

Background Chronic non-specific respiratory symptoms are difficult to manage. This trial
aimed to evaluate the association between baseline fractional exhaled nitric oxide (FeNO) …

Purpose Acute COPD exacerbations account for much of the rising disability and costs
associated with COPD, but data on predictive risk factors are limited. The goal of the current …

Exacerbations in chronic obstructive pulmonary disease (COPD) are major contributors to
worsening lung function, impaired quality of life, emergency healthcare use and COPD …