The lung is composed of airways and lung parenchyma, and the extracellular matrix (ECM)
contains the main building blocks of both components. The ECM provides physical support …

In chronic lung disorders such as in asthma and chronic obstructive pulmonary disease
(COPD) there is increased bronchial angiogenesis and remodelling of pulmonary vessels …

Versican is a proteoglycan that has many different roles in tissue homeostasis and
inflammation. The biochemical structure comprises four different types of the core protein …

Idiopathic pulmonary fibrosis is characterized by the accumulation of fibroblasts/
myofibroblasts and aberrant remodeling of the lung parenchyma. However, the sources of …

An extensive remodelling process, referred to as cervical ripening, takes place in the
cervical tissue during pregnancy and labour. It is recognized as softening and dilation of the …

The development of bleomycin-induced pulmonary fibrosis in rats was studied over a period
of 21 d after an intratracheal instillation of bleomycin. The expression of three small …

Several interactions of cytokines with extracellular matrix molecules are mediated by
proteoglycans, such as biglycan and decorin. Using surface plasmon resonance, we show …

Background Myofibroblasts, proposed as being derived from circulating fibrocytes, are
considered to be important cells in thickening of the basement membrane in patients with …

Background Airway remodeling in COPD includes reorganization of the extracellular matrix.
Proteoglycans play a crucial role in this process as regulators of the integrity of the …

Direct conversion of human fibroblasts into mature and functional neurons, termed induced
neurons (iN s), was achieved for the first time 6 years ago. This technology offers a …