Children with health impairments by heavy metals in an e-waste recycling area

X Zeng, X Xu, HM Boezen, X Huo - Chemosphere, 2016 - Elsevier
E-waste recycling has become a global environmental health issue. Pernicious chemicals
escape into the environment due to informal and nonstandard e-waste recycling activities …

The insulin-like growth factor 1 receptor in cancer: old focus, new future

H Hartog, J Wesseling, HM Boezen… - European journal of …, 2007 - Elsevier
The importance of insulin-like growth factor 1 receptor (IGF-1R) signalling in malignant
behaviour of tumour cells is well established. Currently, development of drugs targeting the …

Meta-analyses on suspected chronic obstructive pulmonary disease genes: a summary of 20 years' research

J Smolonska, C Wijmenga, DS Postma… - American journal of …, 2009 - atsjournals.org
Rationale: Chronic obstructive pulmonary disease (COPD) is a complex disorder with high
mortality worldwide. Studies on the role of candidate genes and their polymorphisms in …

Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction

DF Gudbjartsson, US Bjornsdottir, E Halapi… - Nature …, 2009 - nature.com
Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation
of inflammatory responses and thus have important roles in the pathogenesis of …

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

MS Artigas, DW Loth, LV Wain, SA Gharib, M Obeidat… - Nature …, 2011 - nature.com
Pulmonary function measures reflect respiratory health and are used in the diagnosis of
chronic obstructive pulmonary disease. We tested genome-wide association with forced …

(1 → 3)- β -d-Glucan and Endotoxin in House Dust and Peak Flow Variability in Children

…, I Wouters, H Marike Boezen… - American journal of …, 2000 - atsjournals.org
House dust-associated bacterial endotoxins have been shown to be associated with asthma
severity, and a similar role has been suggested for fungal (1→ 3)-β-d-glucans. In this study …

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis

BD Hobbs, K De Jong, M Lamontagne, Y Bossé… - Nature …, 2017 - nature.com
Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide.
We performed a genetic association study in 15,256 cases and 47,936 controls, with …

[PDF][PDF] Genome analyses of> 200,000 individuals identify 58 loci for chronic inflammation and highlight pathways that link inflammation and complex disorders

S Ligthart, A Vaez, U Võsa, MG Stathopoulou… - The American Journal of …, 2018 - cell.com
C-reactive protein (CRP) is a sensitive biomarker of chronic low-grade inflammation and is
associated with multiple complex diseases. The genetic determinants of chronic …

Lung function and exercise capacity in young adults born prematurely

EJLE Vrijlandt, J Gerritsen, HM Boezen… - American journal of …, 2006 - atsjournals.org
Rationale: Limited information is available about the long-term outcome of lung function and
exercise capacity in young adults born prematurely. Objective: To determine long-term …

[PDF][PDF] Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP

A Zhernakova, EM Festen, L Franke, G Trynka… - The American Journal of …, 2008 - cell.com
The two main phenotypes of inflammatory bowel disease (IBD)—Crohn's disease (CD) and
ulcerative colitis (UC)—are chronic intestinal inflammatory disorders with a complex genetic …