Oxidant-induced autophagy and ferritin degradation contribute to epithelial–mesenchymal transition through lysosomal iron

A Sioutas, LK Vainikka, M Kentson… - Journal of …, 2017 - Taylor & Francis
Purpose Transforming growth factor (TGF)-β1 triggers epithelial–mesenchymal transition
(EMT) through autophagy, which is partly driven by reactive oxygen species (ROS). The aim …

[HTML][HTML] Vitamin D enhances IL-1β secretion and restricts growth of Mycobacterium tuberculosis in macrophages from TB patients

D Eklund, HL Persson, M Larsson, A Welin… - The International …, 2013 - journals.lww.com
The emergence of multidrug-resistant strains of Mycobacterium tuberculosis (MTB), the
bacterium responsible for tuberculosis (TB), has rekindled the interest in the role of …

The health diary telemonitoring and hospital-based home care improve quality of life among elderly multimorbid COPD and chronic heart failure subjects

HL Persson, J Lyth, L Lind - International journal of chronic …, 2020 - Taylor & Francis
Background Elderly, multimorbid patients with advanced chronic obstructive pulmonary
disease (COPD) and/or chronic heart failure (CHF) exhibit poor health-related quality of life …

Elderly patients with COPD require more health care than elderly heart failure patients do in a hospital-based home care setting

HL Persson, J Lyth, AB Wiréhn… - International Journal of …, 2019 - Taylor & Francis
Background Elderly patients with advanced stages of COPD or chronic heart failure (CHF)
often require hospitalization due to exacerbations. We hypothesized that telemonitoring …

The ratio FEV1/FVC and its association to respiratory symptoms—A Swedish general population study

K Torén, L Schiöler, A Lindberg… - Clinical physiology …, 2021 - Wiley Online Library
Chronic airflow limitation (CAL) can be defined as fixed ratio of forced expiratory volume in 1
s (FEV1)/forced vital capacity (FVC)< 0.70 after bronchodilation. It is unclear which is the …

Skeletal myosteatosis is associated with systemic inflammation and a loss of muscle bioenergetics in stable COPD

HL Persson, A Sioutas, M Kentson… - Journal of …, 2022 - Taylor & Francis
Background Common features among patients with more advanced chronic obstructive
pulmonary disease (COPD) are systemic inflammation and a loss of both muscle mass and …

The exacerbation of chronic obstructive pulmonary disease: which symptom is most important to monitor?

PK Jacobson, L Lind, HL Persson - International Journal of …, 2023 - Taylor & Francis
Background GOLD 2023 defines an exacerbation of COPD (ECOPD) by a deterioration of
breathlessness at rest (BaR), mucus and cough. The severity of an ECOPD is determined by …

[HTML][HTML] Pulmonary function and atherosclerosis in the general population: causal associations and clinical implications

G Engström, E Lampa, K Dekkers, YT Lin… - European Journal of …, 2024 - Springer
Reduced lung function is associated with cardiovascular mortality, but the relationships with
atherosclerosis are unclear. The population-based Swedish CArdioPulmonary BioImage …

Unleashing the power of very small data to predict acute exacerbations of chronic obstructive pulmonary disease

PK Jacobson, L Lind, HL Persson - International Journal of …, 2023 - Taylor & Francis
Introduction In this article, we explore to what extent it is possible to leverage on very small
data to build machine learning (ML) models that predict acute exacerbations of chronic …

[HTML][HTML] Does quantitative lung SPECT detect lung abnormalities earlier than lung function tests? Results of a pilot study

P Norberg, HL Persson, B Schmekel, GA Carlsson… - EJNMMI research, 2014 - Springer
Background Heterogeneous ventilation in lungs of individuals with allergies, cigarette
smokers, asthmatics and chronic obstructive pulmonary disease (COPD) patients has been …