T-cell receptors and T-cell subsets were analysed in T-cell receptor transgenic mice
expressing α and β T-cell receptor genes isolated from a male-specific, H–2Db-restricted …

Exclusion and inclusion of T cell receptor (TCR) genes were analyzed in a6 TCR transgenic
mice. Both transgenes are expressed unusually early on the surface of CD4-8-, HSA+, IL-2R …

Antigen-specific human monoclonal antibodies (mAbs) are key candidates for therapeutic
agents. However, the availability of a suitable screening system for antigen-specific antibody …

Detection of cellular response by measuring intracellular calcium,(Ca2+) i with Ca2+-
dependent fluorescent dye are standard approaches to detect ligand-stimulated cells and to …

To identify HLA alleles closely involved in the autoantigen presentation in acquired aplastic
anemia (AA), we studied the HLA allelic loss frequencies of 312 AA patients, including 43 …

Fetal antigen-specific tolerance is important for maintaining allogeneic pregnancies.
Maternal conventional T cells recognize fetal antigens; however, regulatory T (Treg) cells …

The technique of 5′-rapid amplification of cDNA ends (5′-RACE) is widely used to amplify
unknown sequences at the 5′ end of a messenger RNA (mRNA). However, conventional …

Antigen-specific T cell therapy, or T cell receptor (TCR) gene therapy, is a promising
immunotherapy for infectious diseases and cancers. However, a suitable rapid and direct …

CD8+ T cells, the most abundant T cell subset in the decidua, play a critical role in the
maintenance of pregnancy. The majority of decidual CD8+ T cells have an effector memory …

Background: Regulatory T (Treg) cells are necessary for the maintenance of allogenic
pregnancy. However, the repertoire of effector Treg cells at the feto-maternal interface in …