Endpoint selection is a critically important step in clinical trial design. It poses major
challenges for investigators, regulators, and study sponsors, and it also has important …

Obstructive sleep apnea (OSA) has traditionally been seen as a male disease. However, the
importance of OSA in women is increasingly being recognized, along with a number of …

Obstructive sleep apnoea and central sleep apnoea/Cheyne-Stokes respiration are
collectively referred to as sleep-disordered breathing (SDB). Rapidly accumulating evidence …

Background Central sleep apnea is associated with poor prognosis and death in patients
with heart failure. Adaptive servo-ventilation is a therapy that uses a noninvasive ventilator to …

Objectives: This prospective study investigated the prevalence of sleep-disordered
breathing (SDB) and its predictors in patients with stable chronic heart failure (HF) …

1. Background Effective treatment of obstructive sleep apnea (OSA) is an important goal due
to its impact on quality of life, and the known cardiovascular and neurocognitive …

Background: Sleep apnea is common in hospitalized heart failure (HF) patients and is
associated with increased morbidity and mortality. Objectives: The CAT-HF (Cardiovascular …

Aims Central sleep apnoea/Cheyne–Stokes respiration (CSA/CSR) is a risk factor for
increased mortality and morbidity in heart failure (HF). Adaptive servo‐ventilation (ASV) is a …

Continuous positive airway pressure (CPAP) is an effective treatment for obstructive sleep
apnoea (OSA), but treatment compliance is often unsatisfactory. This study investigated the …

Background The emergence of central sleep apnea (CSA) during positive airway pressure
(PAP) therapy has been observed clinically in approximately 10% of obstructive sleep …