User profiles for "author:Hongzhe Li"

Hongzhe Li, PhD

University of Pennsylvania
Verified email at upenn.edu
Cited by 36832

Microbiome, metagenomics, and high-dimensional compositional data analysis

H Li - Annual Review of Statistics and Its Application, 2015 - annualreviews.org
The human microbiome is the totality of all microbes in and on the human body, and its
importance in health and disease has been increasingly recognized. High-throughput …

Isolation and characterization of primary bone marrow mesenchymal stromal cells

H Li, R Ghazanfari, D Zacharaki… - Annals of the New …, 2016 - Wiley Online Library
Bone marrow (BM) contains a rare population of mesenchymal stromal cells (MSCs), which
have been characterized as nonhematopoietic skeletal progenitor cells with central …

[HTML][HTML] Emerging priorities for microbiome research

CM Cullen, KK Aneja, S Beyhan, CE Cho… - Frontiers in …, 2020 - frontiersin.org
Microbiome research has increased dramatically in recent years, driven by advances in
technology and significant reductions in the cost of analysis. Such research has unlocked a …

Linking long-term dietary patterns with gut microbial enterotypes

GD Wu, J Chen, C Hoffmann, K Bittinger, YY Chen… - Science, 2011 - science.org
Diet strongly affects human health, partly by modulating gut microbiome composition. We
used diet inventories and 16 S rDNA sequencing to characterize fecal samples from 98 …

Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis

RA Koeth, Z Wang, BS Levison, JA Buffa, E Org… - Nature medicine, 2013 - nature.com
Intestinal microbiota metabolism of choline and phosphatidylcholine produces
trimethylamine (TMA), which is further metabolized to a proatherogenic species …

The human gut virome: inter-individual variation and dynamic response to diet

S Minot, R Sinha, J Chen, H Li, SA Keilbaugh… - Genome …, 2011 - genome.cshlp.org
Immense populations of viruses are present in the human gut and other body sites.
Understanding the role of these populations (the human “virome”) in health and disease …

Associating microbiome composition with environmental covariates using generalized UniFrac distances

J Chen, K Bittinger, ES Charlson, C Hoffmann… - …, 2012 - academic.oup.com
Motivation: The human microbiome plays an important role in human disease and health.
Identification of factors that affect the microbiome composition can provide insights into …

[HTML][HTML] Archaea and fungi of the human gut microbiome: correlations with diet and bacterial residents

C Hoffmann, S Dollive, S Grunberg, J Chen, H Li… - PloS one, 2013 - journals.plos.org
Diet influences health as a source of nutrients and toxins, and by shaping the composition of
resident microbial populations. Previous studies have begun to map out associations …

[PDF][PDF] Inflammation, antibiotics, and diet as environmental stressors of the gut microbiome in pediatric Crohn's disease

JD Lewis, EZ Chen, RN Baldassano, AR Otley… - Cell host & …, 2015 - cell.com
Abnormal composition of intestinal bacteria—" dysbiosis"—is characteristic of Crohn's
disease. Disease treatments include dietary changes and immunosuppressive anti-TNFα …

Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota

L Albenberg, TV Esipova, CP Judge, K Bittinger… - Gastroenterology, 2014 - Elsevier
Background & Aims The gut microbiota is a complex and densely populated community in a
dynamic environment determined by host physiology. We investigated how intestinal oxygen …