The effects of mechanical forces on lung functions

HR Wirtz, LG Dobbs - Respiration physiology, 2000 - Elsevier
The lung is a dynamic organ that is subjected to mechanical forces throughout development
and adult life. This review article addresses the types of mechanical forces in the lung and …

[HTML][HTML] Lung cancer: current diagnosis and treatment

S Hammerschmidt, H Wirtz - Deutsches Ärzteblatt International, 2009 - ncbi.nlm.nih.gov
Background Much progress has been made in the treatment of lung cancer in the last ten
years (adjuvant chemotherapy, targeted therapy, individualized therapy). Nonetheless, lung …

Calcium mobilization and exocytosis after one mechanical stretch of lung epithelial cells

HRW Wirtz, LG Dobbs - Science, 1990 - science.org
Deep inflation of the lung stimulates surfactant secretion by unknown mechanisms. The
hypothesis that mechanical distension directly stimulates type II cells to secrete surfactant …

Pirfenidone in patients with progressive fibrotic interstitial lung diseases other than idiopathic pulmonary fibrosis (RELIEF): a double-blind, randomised, placebo …

J Behr, A Prasse, M Kreuter, J Johow… - The Lancet …, 2021 - thelancet.com
Background Pirfenidone has been shown to slow disease progression in patients with
idiopathic pulmonary fibrosis (IPF). However, there are few treatment options for progressive …

Management of patients with idiopathic pulmonary fibrosis in clinical practice: the INSIGHTS-IPF registry

J Behr, M Kreuter, MM Hoeper, H Wirtz… - European …, 2015 - Eur Respiratory Soc
After introduction of the new international guidelines on idiopathic pulmonary fibrosis (IPF) in
2011, we investigated clinical management practices for patients with IPF according to …

Effects of nasal high flow on ventilation in volunteers, COPD and idiopathic pulmonary fibrosis patients

J Bräunlich, D Beyer, D Mai, S Hammerschmidt… - Respiration, 2013 - karger.com
Background: A high flow of air applied by large bore nasal cannulae has been suggested to
improve symptoms of chronic respiratory insufficiency. In pediatric patients, nasal high-flow …

Survival and course of lung function in the presence or absence of antifibrotic treatment in patients with idiopathic pulmonary fibrosis: long-term results of the …

J Behr, A Prasse, H Wirtz, D Koschel… - European …, 2020 - Eur Respiratory Soc
Objective There is a paucity of observational data on antifibrotic therapy for idiopathic
pulmonary fibrosis (IPF). We aimed to assess the course of disease of IPF patients with and …

[HTML][HTML] Idiopathic pulmonary arterial hypertension phenotypes determined by cluster analysis from the COMPERA registry

MM Hoeper, C Pausch, E Grünig, H Klose… - The Journal of Heart and …, 2020 - Elsevier
The term idiopathic pulmonary arterial hypertension (IPAH) is used to categorize patients
with pre-capillary pulmonary hypertension of unknown origin. There is considerable …

[HTML][HTML] Exhaled breath condensate cytokine patterns in chronic obstructive pulmonary disease

C Gessner, R Scheibe, M Wötzel, S Hammerschmidt… - Respiratory …, 2005 - Elsevier
Differences in cytokine patterns in stable chronic obstructive pulmonary disease (COPD),
exacerbated COPD, smokers without apparent COPD, and healthy volunteers should be of …

[HTML][HTML] Health related quality of life in patients with idiopathic pulmonary fibrosis in clinical practice: insights-IPF registry

M Kreuter, J Swigris, D Pittrow, S Geier, J Klotsche… - Respiratory …, 2017 - Springer
Abstract Background The INSIGHTS-IPF registry provides one of the largest data sets of
clinical data and self-reported patient related outcomes including health related quality of life …