[HTML][HTML] COVID-19 prevalence and mortality in patients with cancer and the effect of primary tumour subtype and patient demographics: a prospective cohort study

…, I Anil, J Illingworth, J Gibson, J Bhosle… - The Lancet …, 2020 - thelancet.com
Background Patients with cancer are purported to have poor COVID-19 outcomes. However,
cancer is a heterogeneous group of diseases, encompassing a spectrum of tumour …

[HTML][HTML] Systemic treatment of brain metastases in non-small cell lung cancer

…, F McDonald, I Locke, A Minchom, J Bhosle… - European Journal of …, 2020 - Elsevier
Brain metastases (BrMs) are associated with significant morbidity and are found in up to
50% of patients with advanced non-small cell lung cancer (NSCLC). Most of the literature …

Principles of cancer treatment by chemotherapy

J Bhosle, G Hall - Surgery (Oxford), 2009 - Elsevier
This contribution focuses on the indications for chemotherapy, mechanism of action and
classification of chemotherapy, chemotherapy resistance, combination versus single-agent …

Mortality among adults with cancer undergoing chemotherapy or immunotherapy and infected with COVID-19

…, A Ferreira, P Hall, P Ramage, J Bhosle… - JAMA network …, 2022 - jamanetwork.com
Importance Large cohorts of patients with active cancers and COVID-19 infection are
needed to provide evidence of the association of recent cancer treatment and cancer type …

[HTML][HTML] Development of molecularly targeted agents and immunotherapies in small cell lung cancer

A Sharp, J Bhosle, F Abdelraouf, S Popat… - European Journal of …, 2016 - Elsevier
Small cell lung cancer (SCLC) is a smoking-induced malignancy with multiple toxin-
associated mutations, which accounts for 15% of all lung cancers. It remains a clinical …

[HTML][HTML] Clinical activity, tolerability, and long-term follow-up of durvalumab in patients with advanced NSCLC

…, L Calabrň, J Weiss, S Gadgeel, J Bhosle… - Journal of thoracic …, 2019 - Elsevier
Introduction Durvalumab is a selective, high-affinity human immunoglobulin G1 monoclonal
antibody that blocks programmed cell death ligand 1 (PD-L1) binding to programmed death …

[HTML][HTML] Efficient Genotyping of KRAS Mutant Non-Small Cell Lung Cancer Using a Multiplexed Droplet Digital PCR Approach

…, I Kozarewa, D Gonzalez de Castro, J Bhosle… - PloS one, 2015 - journals.plos.org
Droplet digital PCR (ddPCR) can be used to detect low frequency mutations in oncogene-
driven lung cancer. The range of KRAS point mutations observed in NSCLC necessitates a …

[HTML][HTML] Defining the true impact of coronavirus disease 2019 in the at-risk population of patients with cancer

…, S McGrath, D Watkins, J Noble, J Bhosle… - European Journal of …, 2020 - Elsevier
Background In light of the coronavirus disease 2019 (COVID-19) pandemic, cancer centres
in the United Kingdom and Europe re-organised their services at an unprecedented pace …

Involvement of the HER2 pathway in repair of DNA damage produced by chemotherapeutic agents

JJM Boone, J Bhosle, MJ Tilby, JA Hartley… - Molecular cancer …, 2009 - AACR
Abstract HER2 (ErbB2) is overexpressed in up to 30% of human breast cancers. Preclinical
and clinical studies suggest synergy between some chemotherapeutic agents and the …

[HTML][HTML] A randomised study comparing the effectiveness of acupuncture or morphine versus the combination for the relief of dyspnoea in patients with advanced non …

A Minchom, R Punwani, J Filshie, J Bhosle… - European Journal of …, 2016 - Elsevier
Background Dyspnoea is one of the commonest symptoms of lung cancer. Opioids can
reduce dyspnoea. This study investigates acupuncture for relief of breathlessness in lung …