Chronic cough is globally prevalent across all age groups. This disorder is challenging to
treat because many pulmonary and extrapulmonary conditions can present with chronic …

Bronchopulmonary C-fibers and a subset of mechanically sensitive, acid-sensitive
myelinated sensory nerves play essential roles in regulating cough. These vagal sensory …

In 2011, a European Respiratory Society Task Force embarked on a process to determine
the position and clinical relevance of the cough hypersensitivity syndrome, a disorder …

Background Gefapixant is an oral P2X 3 receptor antagonist that has previously shown
efficacy and safety in refractory chronic cough and unexplained chronic cough. We therefore …

Background Preclinical studies suggest that P2X3 receptors are expressed by airway vagal
afferent nerves and contribute to the hypersensitisation of sensory neurons. P2X3 receptors …

Reports from individual centres suggest a preponderance of females with chronic cough.
Females also have heightened cough reflex sensitivity. Here we have reviewed the age and …

BACKGROUND & AIMS: Central sensitization is thought to play a role in chronic cough and
might explain the temporal association between cough and gastroesophageal reflux (GOR) …

Background Gefapixant is a P2X3 receptor antagonist that has shown promise for the
treatment of refractory and unexplained chronic cough. The aim of this study was to evaluate …

Background Inhalation of capsaicin, the extract of hot chili peppers, induces coughing in
both animals and human subjects through activation of transient receptor potential vanilloid …

Rationale: Human lung transplantation is a therapeutic option for selected patients with
advanced cardiopulmonary disease, but long-term survival is limited by chronic rejection …